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4-(甲基亚硝胺)-1-(3-吡啶基)-1-丁醇

4-(甲基亚硝胺)-1-(3-吡啶基)-1-丁醇名称

[ CAS 号 ]:
76014-81-8

[ 中文名 ]:
4-(甲基亚硝胺)-1-(3-吡啶基)-1-丁醇

[ 英文名 ]:
nnal

[英文别名 ]:

rac NNAL
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol
4-[methyl(nitroso)amino]-1-pyridin-3-ylbutan-1-ol
nnal
4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanol
[3H]-(+/-)-NNAL
(4-Methylnitrosoamino)-1-(3-pyridyl)-1-butanol
[14C]-(+/-)-NNAL

4-(甲基亚硝胺)-1-(3-吡啶基)-1-丁醇物理化学性质

[ 密度 ]:
1.16g/cm3

[ 沸点 ]:
430.2ºC at 760 mmHg

[ 分子式 ]:
C₁₀H₁₅N₃O₂

[ 分子量 ]:
209.24500

[ 闪点 ]:
214ºC

[ 精确质量 ]:
209.11600

[ PSA ]:
65.79000

[ LogP ]:
1.50840

[ 折射率 ]:
1.557

[ 储存条件 ]:
2-8°C

4-(甲基亚硝胺)-1-(3-吡啶基)-1-丁醇MSDS

详细MSDS(安全技术说明书)

4-(甲基亚硝胺)-1-(3-吡啶基)-1-丁醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UT5014750

CHEMICAL NAME :: 3-Pyridinemethanol, alpha-(3-(methylnitrosoamino)propyl)-

CAS REGISTRY NUMBER :: 76014-81-8

LAST UPDATED :: 199507

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C10-H15-N3-O2

MOLECULAR WEIGHT :: 209.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 41850 ug/kg

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 11,1017,1990

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 105 mg/kg/7W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors

REFERENCE :: CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 71,25,1993

4-(甲基亚硝胺)-1-(3-吡啶基)-1-丁醇安全信息

[ 符号 ]:

GHS02, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H301 + H311 + H331-H370

[ 警示性声明 ]:
P210-P260-P280-P301 + P310-P311

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
F,T

[ 风险声明 (欧洲) ]:
11-23/24/25-39/23/24/25

[ 安全声明 (欧洲) ]:
7-16-36/37-45

[ 危险品运输编码 ]:
UN1230 - class 3 - PG 2 - Methanol, solution

[ RTECS号 ]:
UT5014750

4-(甲基亚硝胺)-1-(3-吡啶基)-1-丁醇文献

Quantitation of metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone after cessation of smokeless tobacco use.

Cancer Res. 62(1) , 129-34, (2002)

Two major metabolites of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) were previously shown to be highly persistent in human urine after cessation of cigar...

Evidence for endogenous formation of N'-nitrosonornicotine in some long-term nicotine patch users.

Nicotine Tob. Res. 11(1) , 99-105, (2009)

Nitrosation of nicotine or its metabolites in the human body could lead to formation of the 2 carcinogenic tobacco-specific nitrosamines-N'-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyri...

Comparative metabolism of the tobacco-related carcinogens benzo[a]pyrene, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol, and N'- nitrosonornicotine in human hepatic microsomes.

Drug Metab. Dispos. 25(2) , 154-62, (1997)

We compared the metabolism in human hepatic microsomes of three tobacco smoke carcinogens believed to be involved in the induction of cancer in humans: benzo[a]pyrene (BaP),4-(methylnitrosamino)-1-(3-...

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