氟化氢

氟化氢用途

【用途一】
用于有机或无机氟化物的制造，也用于不锈钢、非铁金属酸洗、玻璃器皿磨砂和酸洗、磨砂灯泡的处理等
【用途二】
用作分析试剂，也用于高纯氟化物的制备
【用途三】
是氟盐、氟致冷剂、氟塑料、氟橡胶、氟医药及农药等所必需的氟来源
【用途四】
主要用作含氟化合物的原料，也用于氟化铝和冰晶石的制造，半导体表面刻蚀及用作烷基化的催化剂
【用途五】
是生产冷冻剂“氟里昂”、含氟树脂、有机氟化物和氟的原料。在化工生产中可用作烷基化、聚合、缩合、异构化等有机合成的催化剂。还用于开采某些矿床时腐蚀地层，以及稀土元素、放射性元素的提取。在原子能工业和核武器生产中是制造六氟化铀的原料，也是生产火箭燃料和添加剂的原料，还可用于腐蚀玻璃和浸渍木材等。
【用途六】
用于有机或无机氟化物的制造，如氟碳化合物、氟化钠、氟化铝、六氟化铀和冰晶石等。也用于不锈钢、非铁金属酸洗，玻璃仪表刻度、玻璃器皿和镜子刻花、刻字，以及玻璃器皿抛光、磨砂灯泡和一般灯泡处理、金属石墨乳除硅提纯、金属铸件除砂、石墨灰分的去除、半导体(锗、硅)的制造。也用作染料合成．及其他有机合成的催化剂。还用于电镀、试剂、发酵、陶瓷处理以及含氟树脂和阻燃剂的制造等。
【用途七】
在电子工业中用作强酸性腐蚀剂，可与硝酸、乙酸、氨水、双氧水配合使用。
【用途八】
用于刻蚀玻璃，酸洗金属，制无机类氟盐产品及化学试剂。
【用途九】
测定二氧化硅，制造氟化物，铜类清洁剂，冶金金相分析，硅化合物分析。

氟化氢名称

[ CAS 号 ]:
7664-39-3

[ 中文名 ]:
氢氟酸

[ 英文名 ]:
HYDROFLUORIC ACID

[中文别名 ]:

[英文别名 ]:

hydrogen Fluoride
hydrofluoric
MFCD00011346
Fluorowodor
EINECS 231-634-8
Rubigine
Hydrofluoride
Fluoric acid
fluorhydric acid
Hydrofluoric acid

氟化氢物理化学性质

[ 密度 ]:
1.15 g/mL at 25 °C(lit.)

[ 沸点 ]:
105°C

[ 熔点 ]:
-35°C

[ 分子式 ]:
FH

[ 分子量 ]:
20.00630

[ 闪点 ]:
112°C

[ 精确质量 ]:
20.00620

[ LogP ]:
0.53270

[ 外观性状 ]:
无色气体带有一种辛辣气味

[ 蒸汽密度 ]:
1.27 (vs air)

[ 蒸汽压 ]:
25 mm Hg ( 20 °C)

[ 储存条件 ]:
库房通风低温干燥,与H发孔剂、碱类、氰化物、金属粉末分开存放

[ 稳定性 ]:
Stable. Hygroscopic. Incompatible with glass, alkali metals, light metals, alkaline earth metals

[ 水溶解性 ]:
soluble

氟化氢MSDS

详细MSDS(安全技术说明书)

氟化氢毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MW7875000

CHEMICAL NAME :: Hydrofluoric acid

CAS REGISTRY NUMBER :: 7664-39-3

LAST UPDATED :: 199712

DATA ITEMS CITED :: 54

MOLECULAR FORMULA :: F-H

MOLECULAR WEIGHT :: 20.01

WISWESSER LINE NOTATION :: H F

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Human

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 100 mg/m3/1M

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Sense Organs and Special Senses (Eye) - conjunctive irritation Lungs, Thorax, or Respiration - cough

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 143 mg/kg

TOXIC EFFECTS :: Cardiac - arrhythmias (including changes in conduction) Vascular - BP lowering not characterized in autonomic section Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Human

DOSE/DURATION :: 50 ppm/30M

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1276 ppm/1H

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Behavioral - changes in motor activity (specific assay) Gastrointestinal - changes in structure or function of salivary glands

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 342 ppm/1H

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - corneal damage Sense Organs and Special Senses (Eye) - effect, not otherwise specified Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - tremor Lungs, Thorax, or Respiration - respiratory depression

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 1774 ppm/1H

TOXIC EFFECTS :: Behavioral - coma Lungs, Thorax, or Respiration - cyanosis Gastrointestinal - other changes

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 260 mg/m3/7H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 4327 ppm/15M

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 112 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 300 ug/m3/24H/22W-C

TOXIC EFFECTS :: Behavioral - alteration of classical conditioning Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 252 ug/m3/6H/17W-I

TOXIC EFFECTS :: Blood - changes in erythrocyte (RBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - monoamine oxidase Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 470 ug/m3/4H

SEX/DURATION :: female 1-22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 4980 ug/m3/4H

SEX/DURATION :: female 1-22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :: DNA damage

TYPE OF TEST :: Sex chromosome loss and nondisjunction

MUTATION DATA

TEST SYSTEM :: Rodent - rat

REFERENCE :: CYGEDX Cytology and Genetics (English Translation). Translation of TGANAK. (Allerton Press Inc., 150 Fifth Ave., New York, NY 10011) V.8- 1974- Volume(issue)/page/year: 9(1),40,1975 *** REVIEWS *** ACGIH TLV-CL 2.3 mg/m3 (3 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW AMSSAQ Acta Medica Scandinavica, Supplement. (Almqvist & Wiksell, POB 45150, S-10430 Stockholm, Sweden) No.1-730, 1921-88. Volume(issue)/page/year: 400,5,1963 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 3 ppm (2 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,131,1971 OSHA PEL (Gen Indu):8H TWA 3 ppm CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 3 ppm (2 mg(F)/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 3 ppm (2 mg(F)/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 3 ppm (2 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 2 ppm (2 mg/m3) JAN 1993 OEL-AUSTRALIA:TWA 3 ppm (2.5 mg/m3) JAN 1993 OEL-BELGIUM:STEL 3 ppm (2.6 mg/m3) JAN 1993 OEL-DENMARK:TWA 2 ppm (1.6 mg/m3) JAN 1993 OEL-FINLAND:STEL 6 ppm;Skin JAN 1993 OEL-FRANCE:STEL 3 ppm (2.5 mg/m3) JAN 1993 OEL-GERMANY:TWA 3 ppm (2 mg/m3) JAN 1993 OEL-HUNGARY:TWA 0.5 mg/m3;STEL 1 mg/m3 JAN 1993 OEL-JAPAN:TWA 3 ppm (25 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 3 ppm (2 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 3 ppm (2 mg/m3) JAN 1993 OEL-POLAND:TWA 0.5 mg/m3 JAN 1993 OEL-RUSSIA:TWA 3 ppm (0.1 mg/m3);STEL 0.5 mg/m3 JAN 1993 OEL-SWEDEN:STEL 2 ppm (1.7 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 1.8 ppm (1.5 mg/m3);STEL 3.6 ppm (3 mg/m3) JAN 1993 OEL-TURKEY:TWA 3 ppm (2 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 3 ppm (2.5 mg/m3);STEL 6 ppm (5 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO HYDROGEN FLUORIDE-air:10H TWA 3 ppm;STEL 6 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 38550 No. of Facilities: 6590 (estimated) No. of Industries: 97 No. of Occupations: 68 No. of Employees: 68886 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 38550 No. of Facilities: 11332 (estimated) No. of Industries: 96 No. of Occupations: 89 No. of Employees: 189051 (estimated) No. of Female Employees: 68792 (estimated)

氟化氢安全信息

[ 符号 ]:

GHS05, GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300 + H310 + H330-H314

[ 警示性声明 ]:
P260-P280-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338-P403 + P233

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
C:Corrosive

[ 风险声明 (欧洲) ]:
R26/27/28;R35

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45-S7/9-S36/37-S28-S36

[ 危险品运输编码 ]:
UN 1790 8/PG 2

[ WGK德国 ]:
2

[ RTECS号 ]:
MW7875000

[ 包装等级 ]:
II

[ 危险类别 ]:
8

[ 海关编码 ]:
2811110000

氟化氢合成路线

详细合成路线

氟化氢上下游产品

氟化氢上游产品

氟化氢下游产品

氟化氢制备

1.硫酸法：将干燥后的萤石粉和硫酸按配比1：(1.2～1.3)混合，送入回转式反应炉内进行反应，炉内气相温度控制在280℃±10℃。反应后的气体进入粗馏塔，除去大部分硫酸、水分和萤石粉，塔釜温度控制在100～110℃，塔顶温度为35～40℃。粗氟化氢气体再经脱气塔冷凝为液态，塔釜温度控制在20～23℃，塔顶温度为-8℃±1℃，然后进入精馏塔精馏，塔釜温度控制在30～40℃，塔顶温度为19.6℃±0.5℃。精制后的氟化氢用水吸收，即得氢氟酸产品。其

2.将工业级氢氟酸通过蒸馏提纯，冷凝分离除去杂质，并经微孔滤膜过滤除去尘埃颗粒，制得无色透明的电子级氢氟酸。

3.以钢瓶工业氟化氢为原料，用聚乙烯管子接入洗涤瓶，打开钢瓶阀门，让氟化氢气体慢慢通入装有合格电导水的吸收器中，得分析纯氢氟酸。

4.以工业氢氟酸为原料，先用高锰酸钾氧化原料中的有机物和亚硫酸，然后根据原料中的杂质含量加入碳酸钾(或氟化钾和碳酸钡)，以除去硫酸、氟磺酸、氟硅酸和盐酸等杂质(生成的不挥发物留于底层) 。搅拌均匀，静置，再搅拌，反应完全后，升温蒸馏，收集馏出物于干净犘犞犆 ( 聚氯乙烯) 容器内，即为试剂氢氟酸。

5.生产氢氟酸有采用萤石及磷矿石两种原料路线。而以萤石为原料的硫酸法是工业上普遍采用的方法。将干燥后的萤石粉和硫酸按配比1∶(1.2～1.3)混合，经高温分解、粗馏、精馏及水吸收而制得氢氟酸。

氟化氢海关

[ 海关编码 ]: 2811110000

氟化氢文献

Preservation of the structure of enzymatically-degraded bovine vitreous using synthetic proteoglycan mimics.

Invest. Ophthalmol. Vis. Sci. 55(12) , 8153-62, (2014)

Vitreous liquefaction and subsequent posterior vitreous detachment can lead to several sight-threatening diseases, including retinal detachment, macular hole and macular traction syndrome, nuclear cat...

In vitro antiviral and immunomodulatory activity of arbidol and structurally related derivatives in herpes simplex virus type 1-infected human keratinocytes (HaCat).

J. Med. Microbiol. 63(Pt 11) , 1474-83, (2014)

Arbidol (ARB) is an antiviral drug that has broad-spectrum activity against a number of viral infections. To date, there are no specific data regarding its effects against a herpesvirus. Here, the in ...

Differential Patterns and Determinants of Cardiac Autonomic Nerve Dysfunction during Endotoxemia and Oral Fat Load in Humans.

PLoS ONE 10(4) , e0124242, (2015)

The autonomic nervous system (ANS) plays an important role in regulating the metabolic homeostasis and controlling immune function. ANS alterations can be detected by reduced heart rate variability (H...

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氟化氢相关知识

氟化氢的作用和制备

2022-04-26 09:02:39

作为半导体市场的新贵，韩国在半导体市场的份额越来越大，日韩之间的贸易斗争也是越打越烈，日本深圳实施了对韩国的半导体材料禁售政策，而这其中，氟化氢，也就是我们常说的氢氟酸就是其中非常重要的一项。　　氟化氢，CAS号7664-39-3，据化源网资料显示，是一种无色而又带有辛辣气味的刺激性气体，易溶于水...

氟化氢