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罗硝唑

罗硝唑用途

Ronidazole可抗原生动物。

罗硝唑名称

[ CAS 号 ]:
7681-76-7

[ 中文名 ]:
洛硝哒唑

[ 英文名 ]:
Ronidazole

[中文别名 ]:

[英文别名 ]:

Ridazole
Ridzol P
Dugro
(1-Methyl-5-nitroimidazole-2-yl)methyl Carbamate
2-Carbamoyloxymethyl-1-methyl-5-nitro-imidazol
1-Methyl-2-[(carbamoyloxy)methyl]-5-nitroimidazole
Ridzol
MCMN
2-carbamoyloxymethyl-1-methyl-5-nitro-1H-imidazole
Ronidazole

罗硝唑生物活性

[ 描述 ]:

Ronidazole可抗原生动物。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 寄生物

研究领域 >> 感染

[参考文献]

[1]. Lim, S., et al., Efficacy of ronidazole for treatment of cats experimentally infected with a Korean isolate of Tritrichomonas foetus. Korean J Parasitol, 2012. 50(2): p. 161-4.

[相关活性小分子]

罗硝唑物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 沸点 ]:
502.3±30.0 °C at 760 mmHg

[ 熔点 ]:
167-169°

[ 分子式 ]:
C₆H₈N₄O₄

[ 分子量 ]:
200.152

[ 闪点 ]:
257.6±24.6 °C

[ 精确质量 ]:
200.054550

[ PSA ]:
115.96000

[ LogP ]:
-0.45

[ 蒸汽压 ]:
0.0±1.3 mmHg at 25°C

[ 折射率 ]:
1.651

[ 储存条件 ]:
−20°C

罗硝唑MSDS

详细MSDS(安全技术说明书)

罗硝唑毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NI6803000

CHEMICAL NAME :: Imidazole-2-methanol, 1-methyl-5-nitro-, carbamate (ester)

CAS REGISTRY NUMBER :: 7681-76-7

BEILSTEIN REFERENCE NO. :: 0886221

LAST UPDATED :: 199612

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C6-H8-N4-O4

MOLECULAR WEIGHT :: 200.18

WISWESSER LINE NOTATION :: T5N CNJ A1 B1OVZ ENW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: Micronucleus test

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 40,289,1976

罗硝唑安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
NI6803000

[ 海关编码 ]:
2933290090

罗硝唑上下游产品

罗硝唑上游产品

罗硝唑下游产品

罗硝唑海关

[ 海关编码 ]: 2933290090

[ 中文概述 ]:
2933290090. 其他结构含非稠合咪唑环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

罗硝唑文献

Determination of nitroimidazole residues in aquaculture tissue using ultra high performance liquid chromatography coupled to tandem mass spectrometry.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 960 , 105-15, (2014)

An UHPLC-MS/MS method was developed for the quantitative confirmatory analysis of residues of nitroimidazole drugs (dimetridazole, ipronidazole, metronidazole, ornidazole and ronidazole) and their cor...

Simultaneous determination of 15 nitroimidazoles in cosmetics by HPLC coupled with electrospray ionization- tandem mass spectrometry.

J. AOAC Int. 97(6) , 1538-45, (2015)

A sensitive and reliable analytical method based on HPLC/MSIMS has been developed for the simultaneous determination of 15 nitroimidazoles in cosmetics. A diversity of cosmetic samples, including powd...

Tritrichomonas foetus infection in cats with diarrhoea in a rescue colony in Italy.

J. Feline Med. Surg. 11(2) , 131-4, (2009)

Faecal samples from 74 cats with chronic large bowel diarrhoea that were living in a rescue colony in Italy, were submitted for assessment of Tritrichomonas foetus by direct microscopy of faecal smear...

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罗硝唑