铬酸钾

铬酸钾用途

【用途一】
主要用于制造化学试剂及颜料等
【用途二】
用作分析试剂、氧化剂、媒染剂和金属防锈剂
【用途三】
用于铬酸盐的制造。用作氧化剂，印染的媒染剂。用于墨水、颜料、搪瓷、金属防腐等。
【用途四】
点滴分析测定钡、银等，测定　农药DDT及五氯酚钠的含量等。

铬酸钾名称

[ CAS 号 ]:
7789-00-6

[ 中文名 ]:
铬酸钾

[ 英文名 ]:
Potassium chromate

[中文别名 ]:

铬酸二钾

[英文别名 ]:

Potassium chromate
EINECS 232-140-5
MFCD00011368

铬酸钾物理化学性质

[ 密度 ]:
1.00 g/mL at 20 °C

[ 熔点 ]:
971 °C(lit.)

[ 分子式 ]:
CrK₂O₄

[ 分子量 ]:
194.19000

[ 精确质量 ]:
193.84800

[ PSA ]:
80.26000

[ 外观性状 ]:
柠檬-黄色晶体

[ 蒸汽密度 ]:
6.7 (vs air)

[ 储存条件 ]:
2-8°C

[ 稳定性 ]:
Stable. Strong oxidizing agent - contact with combustible materials may lead to fire or violent reaction. Incompatible with strong reducing agents, combustible materials.

[ 水溶解性 ]:
640 g/L (20 ºC)

铬酸钾MSDS

详细MSDS(安全技术说明书)

铬酸钾毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GB2940000

CHEMICAL NAME :: Chromic acid (H2CrO4), dipotassium salt

CAS REGISTRY NUMBER :: 7789-00-6

LAST UPDATED :: 199712

DATA ITEMS CITED :: 68

MOLECULAR FORMULA :: Cr-O4.2K

MOLECULAR WEIGHT :: 194.20

WISWESSER LINE NOTATION :: KA2 CR-O2-Q2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 32 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 19 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Gastrointestinal - nausea or vomiting

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 2900 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 12 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 11 mg/kg

TOXIC EFFECTS :: Behavioral - food intake (animal) Behavioral - coma Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 60 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 209 mg/kg/2W-I

TOXIC EFFECTS :: Liver - other changes Kidney, Ureter, Bladder - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - multiple enzyme effects

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1600 mg/kg/62W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - leukemia Lungs, Thorax, or Respiration - bronchiogenic carcinoma

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 30 mg/kg

SEX/DURATION :: female 8-10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 60 mg/kg

SEX/DURATION :: female 8-10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

TYPE OF TEST :: Specific locus test

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: Specific locus test

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: Sister chromatid exchange

MUTATION DATA

TYPE OF TEST :: DNA damage

TEST SYSTEM :: Mammal - species unspecified Lymphocyte

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 368,235,1996 *** REVIEWS *** ACGIH TLV-TWA 0.05 mg(Cr)/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-Confirmed human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Human Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 49,49,1990 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 23,205,1980 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 23,205,1980 IARC Cancer Review:Group 1 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 49,49,1990 TOXICOLOGY REVIEW PEXTAR Progress in Experimental Tumor Research. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1960- Volume(issue)/page/year: 12,102,1969 TOXICOLOGY REVIEW 85DHAX "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77 Volume(issue)/page/year: Cr,22,1974 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 0.5 mg(Cr)/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,35,1971 OSHA PEL (Gen Indu):CL 0.1 mg(CrO3)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):CL 0.1 mg(CrO3)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):CL 0.1 mg(CrO3)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):CL 0.1 mg(CrO3)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO CHROMIUM(VI)-air:10H CA TWA 0.001 mg(Cr)/m3 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 60370 No. of Facilities: 3305 (estimated) No. of Industries: 48 No. of Occupations: 35 No. of Employees: 24042 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 60370 No. of Facilities: 2219 (estimated) No. of Industries: 35 No. of Occupations: 34 No. of Employees: 25411 (estimated) No. of Female Employees: 5985 (estimated)

铬酸钾安全信息

[ 符号 ]:

GHS06, GHS08, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H315-H317-H319-H335-H340-H350i-H410

[ 警示性声明 ]:
P201-P273-P280-P301 + P310 + P330-P304 + P340 + P312-P308 + P313

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T:Toxic

[ 风险声明 (欧洲) ]:
R22;R36/37/38;R43;R46;R49;R50/53;R8

[ 安全声明 (欧洲) ]:
S53-S45-S60-S61-S36/37-S26

[ 危险品运输编码 ]:
UN 3288 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
GB2940000

[ 包装等级 ]:
III

[ 危险类别 ]:
5.1

铬酸钾制备

1. 中和法

将重铬酸钾溶解于母液和水中，加入反应器，在搅拌下加入氢氧化钾进行中和反应，生成铬酸钾呈弱碱性，经蒸发浓缩，冷却结晶，固液分离，干燥，制得铬酸钾成品。其反应方程式如下：

分离出的母液，返回溶解工序用于溶解重铬酸钾。 2. 1取2份（质量）重铬酸钾粉末与4份沸腾水混合，在搅拌下加入碳酸钾，直至溶液显弱碱性（约需加入1份）。随后进行过滤，冷却滤液即析出铬酸钾结晶。将母液再蒸发，还可得到结晶。 3.将纯三氧化铬CrO3放入铂皿中，加入纯氢氧化钾水溶液，直至成黄色。析出的结晶可经再结晶加以精制。精制法在水溶液中反复进行再结晶，其次数至少三次。产品存于盛有氢氧化钾的干燥器中。 4. 采用中和法。将重铬酸钾溶解于母液和水中，加入反应器，在搅拌下加入氢氧化钾进行中和反应，生成的铬酸钾呈弱酸性，经蒸发浓缩、冷却结晶、固液分离、干燥，制得铬酸钾成品。 5 ．用蒸馏水加热溶解工业铬酸钾，使溶液相对密度为1.41，加入适量三氧化铬或碳酸钾，使溶液对酚
酞呈弱碱性，趁热过滤，滤去不溶物，滤液冷却结晶，甩干即可。
6．将1份工业品重铬酸钾溶解到2.5份热水中，边搅拌边缓慢加入化学纯碳酸钾：反应结束后加入少量化学纯氢氧化钾，使溶液对酚酞呈弱碱性。保温1h，过滤。滤液加热浓缩至结晶薄膜出现，不需搅拌进行冷却。将上层清液吸出，双层滤纸过滤，滤液在不断搅拌下（用玻棒）加热蒸发至原体积1／4，冷却结晶，抽滤，结晶于40～80℃干燥，得优级纯或分析纯品。

铬酸钾文献

DNA double-strand breaks by Cr(VI) are targeted to euchromatin and cause ATR-dependent phosphorylation of histone H2AX and its ubiquitination.

Toxicol. Sci. 143(1) , 54-63, (2014)

Hexavalent chromium is a human respiratory carcinogen that undergoes intracellular activation in vivo primarily via reduction with ascorbate. Replication of Cr-adducted DNA triggers mismatch repair th...

Disrupting monotony during social isolation stress prevents early development of anxiety and depression like traits in male rats.

BMC Neurosci. 16 , 2, (2015)

Although there have been several reports on social isolation induced mood alterations, the independent contribution of monotonous environment in mediating mood alterations has been less studied. In vi...

Long-Term Provision of Environmental Resources Alters Behavior but not Physiology or Neuroanatomy of Male and Female BALB/c and C57BL/6 Mice.

J. Am. Assoc. Lab. Anim. Sci. 54 , 718-30, (2015)

Few studies have evaluated the long-term effects of providing environmental resources to mice. This consideration is important given that mice are often maintained in vivaria for months. We evaluated ...

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铬酸钾