D,L-苏-PDMP

D,L-苏-PDMP用途

DL-threo-PDMP inhibits glucosylceramide synthase by 33 and 48% in MDCK cell homogenates when used at concentrations of 5 and 10 M.

D,L-苏-PDMP名称

[ CAS 号 ]:
80938-69-8

[ 中文名 ]:
D,L-苏-PDMP

[ 英文名 ]:
DL-threo-PDMP (hydrochloride)

[英文别名 ]:

d,l-threo-pdmp hcl
dl-pdmp
dl-threo-pdmp,hydrochloride

D,L-苏-PDMP物理化学性质

[ 沸点 ]:
607.4ºC at 760 mmHg

[ 分子式 ]:
C₂₃H₃₉ClN₂O₃

[ 分子量 ]:
427.020

[ 闪点 ]:
321.2ºC

[ 精确质量 ]:
426.264923

[ PSA ]:
61.80000

[ LogP ]:
4.80850

[ 储存条件 ]:
-20°C，密闭，干燥

D,L-苏-PDMPMSDS

详细MSDS(安全技术说明书)

D,L-苏-PDMP安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
26

[ 危险品运输编码 ]:
NONH for all modes of transport

D,L-苏-PDMP文献

Effects of D-threo-PDMP, an inhibitor of glucosylceramide synthetase, on expression of cell surface glycolipid antigen and binding to adhesive proteins by B16 melanoma cells.

J. Cell Physiol. 141 , 573-583, (1989)

Incubating B16 melanoma cells with an inhibitor of glucosylceramide (GlcCer) synthetase, D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D-threo-PDMP), led to a considerable decrease in the ...

Inhibition of glycosphingolipid synthesis by threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP) and the modulation of IL-1beta-stimulated expression of inducible nitric oxide synthase in rat aortic smooth muscle cells.

Br. J. Pharmacol. 123 , 906-910, (1998)

1. The composition of glycosphingolipids is altered in atherosclerotic tissue. In order to study the possible modulation of interleukin-1beta (IL-1beta)-induced expression of inducible nitric oxide sy...

Radin, et al.

J. Lipid Res. 26 , 183-213, (1993)

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