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10-羟基华法林

10-羟基华法林名称

[ CAS 号 ]:
83219-99-2

[ 中文名 ]:
10-羟基华法林

[ 英文名 ]:
10-HYDROXYWARFARIN

[英文别名 ]:

10-Hydroxywarfarin

10-羟基华法林物理化学性质

[ 密度 ]:
1.388 g/cm3

[ 沸点 ]:
509.2ºC at 760 mmHg

[ 熔点 ]:
183-185ºC

[ 分子式 ]:
C₁₉H₁₆O₅

[ 分子量 ]:
324.32700

[ 闪点 ]:
185ºC

[ 精确质量 ]:
324.10000

[ PSA ]:
87.74000

[ LogP ]:
2.58040

[ 折射率 ]:
1.656

10-羟基华法林MSDS

详细MSDS(安全技术说明书)

10-羟基华法林安全信息

[ 符号 ]:

GHS05, GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300-H318

[ 警示性声明 ]:
P264-P280-P301 + P310-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T: Toxic;

[ 风险声明 (欧洲) ]:
25-41

[ 安全声明 (欧洲) ]:
26-39-45

[ 危险品运输编码 ]:
UN 2811 6

10-羟基华法林文献

Investigation of two-dimensional high performance liquid chromatography approaches for reversed phase resolution of warfarin and hydroxywarfarin isomers.

J. Chromatogr. A. 1363 , 200-6, (2014)

Several offline and online 2D HPLC methods were investigated for the reversed phase resolution of a complex mixture of closely related warfarin and hydroxywarfarin isomers. By combining reversed phase...

Hydroxywarfarin metabolites potently inhibit CYP2C9 metabolism of S-warfarin.

Chem. Res. Toxicol. 23(5) , 939-45, (2010)

Coumadin (R/S-warfarin) anticoagulant therapy poses a risk to over 50 million Americans, in part due to interpersonal variation in drug metabolism. Consequently, it is important to understand how meta...

Contribution of three CYP3A isoforms to metabolism of R- and S-warfarin.

Drug Metab. Lett. 4(4) , 213-9, (2010)

Effective coumadin (R/S-warfarin) therapy is complicated by inter-individual variability in metabolism. Recent studies have demonstrated that CYP3A isoforms likely contribute to patient responses and ...

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