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二苯甲基哌嗪

二苯甲基哌嗪用途

H1-受体拮抗剂奥沙米特（Oxatomide）的中间体。

二苯甲基哌嗪名称

[ CAS 号 ]:
841-77-0

[ 中文名 ]:
二苯甲基哌嗪

[ 英文名 ]:
N-Benzhydrylpiperazine

[中文别名 ]:

[英文别名 ]:

Piperazine, 1-(diphenylmethyl)-
EINECS 212-667-7
N-Benzhydrylpiperazine
1-benzhydrylpiperazine
MFCD00038379
Piperazine, 1- (diphenylmethyl)-
1-(Diphenylmethyl)piperazine

二苯甲基哌嗪物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
365.1±32.0 °C at 760 mmHg

[ 熔点 ]:
90-93 °C

[ 分子式 ]:
C₁₇H₂₀N₂

[ 分子量 ]:
252.354

[ 闪点 ]:
140.5±16.1 °C

[ 精确质量 ]:
252.162643

[ PSA ]:
15.27000

[ LogP ]:
2.85

[ 外观性状 ]:
略黄色固体

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.584

[ 储存条件 ]:
存放于惰性气体之中;避免空气

[ 水溶解性 ]:
0.45 g/L (20 ºC)

二苯甲基哌嗪MSDS

二苯甲基哌嗪毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TL6465000

CHEMICAL NAME :: Piperazine, 1-(diphenylmethyl)-

CAS REGISTRY NUMBER :: 841-77-0

BEILSTEIN REFERENCE NO. :: 0222773

LAST UPDATED :: 199712

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C17-H20-N2

MOLECULAR WEIGHT :: 252.39

WISWESSER LINE NOTATION :: T6M DNTJ DYR&R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (2),28,1997

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (2),28,1997

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 38 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532, Japan) V.29- 1970- Volume(issue)/page/year: 31,453,1972

二苯甲基哌嗪安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
TL6465000

[ 包装等级 ]:
I; II; III

[ 海关编码 ]:
2942000000

二苯甲基哌嗪合成路线

二苯甲基哌嗪上下游产品

二苯甲基哌嗪上游产品

二苯甲基哌嗪下游产品

二苯甲基哌嗪制备

1. 制备方法：将二苯甲醇9.2克加至浓盐酸53毫升中，搅拌回流1小时，冷却。用乙醚提取，无水硫酸钠干燥2小时，蒸出乙醚，残液转入滴液漏斗中备用。将无水哌嗪12.8克加至甲苯40毫升中，加热至80℃。滴加上述二苯氯甲烷，滴毕，保持80-90℃反应3小时，甲苯层用稀盐酸提取3次，提取液用氢氧化钠碱化，得淡黄色固体7.7克，收率61%，进一步提纯可用乙醇重结晶。

二苯甲基哌嗪海关

[ 海关编码 ]: 2933599090

[ 中文概述 ]:
2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

二苯甲基哌嗪文献

Quantification of cyclizine and norcyclizine in human plasma by liquid chromatography-tandem mass spectrometry (LC-MS/MS).

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 879(9-10) , 605-9, (2011)

A rapid and simple liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay was developed and validated for quantification of cyclizine and its main metabolite norcyclizine in human plasma. Sam...

Oxidative metabolism of cinnarizine in rat liver microsomes.

Biochem. Pharmacol. 44(7) , 1471-4, (1992)

The oxidative metabolism of cinnarizine (CZ) [1-(diphenylmethyl)-4-(3-phenyl-2-propenyl)-piperazine] to 1-(diphenylmethyl)piperazine (M-1), 1-(diphenylmethyl)-4-[3-(4'-hydroxyphenyl)-2-propenyl]pipera...

The reactions of polyhalogenated-2-nitro-1, 3-butadiene with alkylthio, thiomorpholine and piperazine derivatives. Ibis C and Deniz NG.

Indian J. Chem. B 47(9) , 1407, (2008)

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