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伊马咪啶

伊马咪啶用途

非强心苷、非儿茶酚胺的强心药物。用于心力衰竭。

伊马咪啶名称

[ CAS 号 ]:
84243-58-3

[ 中文名 ]:
伊马咪啶

[ 英文名 ]:
IMAZODAN

[中文别名 ]:

亚马佐旦

[英文别名 ]:

Imazodanum
Cl 914
Imazodanum [Latin]
IMAZODAN
MFCD00867109
Imazodan [INN]

伊马咪啶物理化学性质

[ 密度 ]:
1.34g/cm3

[ 分子式 ]:
C₁₃H₁₂N₄O

[ 分子量 ]:
240.26100

[ 精确质量 ]:
240.10100

[ PSA ]:
59.28000

[ LogP ]:
1.25080

[ 折射率 ]:
1.696

[ 储存条件 ]:
室温，密封，干燥

伊马咪啶MSDS

伊马咪啶安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2933990090

伊马咪啶合成路线

伊马咪啶上下游产品

伊马咪啶上游产品

伊马咪啶下游产品

伊马咪啶制备

氟苯、无水三氯化铝和二氯甲烷混合，搅拌下加入琥珀酸酐。加毕回流，得4-(4-氟苯基)-4-氧代丁酸，收率62.2%。将其和咪唑及二甲亚砜混合后，滴加到甲醇钠中。105℃反应得4-[4-(1H-咪唑-1-基)苯基1-4-氧代丁酸，收率61.5%。然后和水合肼在乙醇中反应，得伊马唑旦，收率92%，熔点212--213℃。

伊马咪啶海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

伊马咪啶文献

New mechanisms for positive inotropic agents: focus on the discovery and development of imazodan.

Cardiovasc. Drugs Ther. 3(1) , 29-42, (1989)

Intense efforts during the last decade to identify a useful positive inotropic agent to replace digitalis for the treatment of congestive heart failure have led to the discovery of several dozen poten...

Determination of 4,5-dihydro-6-[4-(1H-imidazol-1-yl) phenyl]-3(2H)-pyridazinone hydrochloride, a new cardiotonic, in plasma and urine by reversed-phase high-performance liquid chromatography.

J. Chromatogr. A. 336(2) , 446-51, (1984)

Effect of a new phosphodiesterase type III inhibitor as a coronary vasodilator and positive inotropic agent.

Cardiovasc. Res. 21(8) , 593-600, (1987)

Isolated rabbit coronary arteries, aortic strips, and a working rabbit heart preparation were used to assess the positive inotropic and vasodilator effects of a newly developed positive inotropic comp...

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