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四氢化邻苯二甲酸酐

四氢化邻苯二甲酸酐用途

【用途一】
1，2，3，6-四氢邻苯二甲酸酐(简称四氢苯酐，△⁴)，是制备杀虫剂胺菊酯和杀菌剂克菌丹的中间体，也可用于制备醇酸树脂、不饱和聚酯树脂、增塑剂和固化剂等。

四氢化邻苯二甲酸酐名称

[ CAS 号 ]:
85-43-8

[ 中文名 ]:
四氢化邻苯二甲酸酐

[ 英文名 ]:
1,2,3,6-Tetrahydrophthalic anhydride

[中文别名 ]:

[英文别名 ]:

MFCD00005916
3a,4,7,7a-Tetrahydroisobenzofuran-1,3-dione
EINECS 201-605-4
Tetrahydrophthalic Anhydride
1,2,3,6-Tetrahydrophthalic anhydride

四氢化邻苯二甲酸酐物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
305.6±42.0 °C at 760 mmHg

[ 熔点 ]:
101-102°C

[ 分子式 ]:
C₈H₈O₃

[ 分子量 ]:
152.147

[ 闪点 ]:
148.3±25.1 °C

[ 精确质量 ]:
152.047348

[ PSA ]:
43.37000

[ LogP ]:
0.10

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.529

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、胺分开存放

四氢化邻苯二甲酸酐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GW5775000

CHEMICAL NAME :: 4-Cyclohexene-1,2-dicarboxylic anhydride

CAS REGISTRY NUMBER :: 85-43-8

BEILSTEIN REFERENCE NO. :: 0082340

LAST UPDATED :: 199710

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C8-H8-O3

MOLECULAR WEIGHT :: 152.16

WISWESSER LINE NOTATION :: T56 BVOV GUTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,322,1986

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,322,1986 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LC - Lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >294 mg/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 29(12),37,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 29(12),37,1985

TYPE OF TEST :: LC - Lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >294 mg/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 29(12),37,1985

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 7,780,1955

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 29(12),37,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 3500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 29(12),37,1985 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2931 No. of Facilities: 39 (estimated) No. of Industries: 3 No. of Occupations: 9 No. of Employees: 1584 (estimated) No. of Female Employees: 547 (estimated)

四氢化邻苯二甲酸酐安全信息

[ 风险声明 (欧洲) ]:
R41

[ 安全声明 (欧洲) ]:
S26-S36/37/39

[ 危险品运输编码 ]:
2698

[ 包装等级 ]:
III

[ 危险类别 ]:
8

四氢化邻苯二甲酸酐合成路线

详细合成路线

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四氢化邻苯二甲酸酐上游产品

四氢化邻苯二甲酸酐下游产品

四氢化邻苯二甲酸酐制备

将顺丁烯二酸酐加入反应釜，加热至全部熔融后，搅拌加入溶剂苯，搅拌混溶后，继续搅拌并升温至100-110℃，通入丁二烯进行加成反应18-22h，反应结束后将溶剂苯蒸出，经冷凝器冷却后回收循环使用，反应液经抽滤、干燥即得成品。