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2,5-二氟溴苄

2,5-二氟溴苄名称

[ CAS 号 ]:
85117-99-3

[ 中文名 ]:
2,5-二氟苄溴

[ 英文名 ]:
2,5-Difluorobenzyl bromide

[中文别名 ]:

[英文别名 ]:

2,5-Difluorobenzyl bromide
α-Bromo-2,5-difluorotoluene
2-(Bromomethyl)-1,4-difluorobenzene
Benzene, 2-(bromomethyl)-1,4-difluoro-
EINECS 285-651-0
FR DF B1E
MFCD00009897

2,5-二氟溴苄物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
187.9±25.0 °C at 760 mmHg

[ 熔点 ]:
8ºC

[ 分子式 ]:
C₇H₅BrF₂

[ 分子量 ]:
207.015

[ 闪点 ]:
15.6±0.0 °C

[ 精确质量 ]:
205.954269

[ LogP ]:
3.09

[ 外观性状 ]:
透明黄色液体

[ 蒸汽压 ]:
0.8±0.3 mmHg at 25°C

[ 折射率 ]:
1.523

[ 储存条件 ]:
Flammables area

2,5-二氟溴苄MSDS

2,5-二氟溴苄安全信息

[ 符号 ]:

GHS02, GHS05

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H314

[ 警示性声明 ]:
P210-P280-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
F:Flammable;C:Corrosive;

[ 风险声明 (欧洲) ]:
R11;R22;R34

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45-S16

[ 危险品运输编码 ]:
UN 2924 3/PG 2

[ WGK德国 ]:
3

[ 包装等级 ]:
III

[ 危险类别 ]:
8

2,5-二氟溴苄合成路线

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2,5-二氟溴苄文献

Aryl sulfones: a new class of gamma-secretase inhibitors.

Bioorg. Med. Chem. Lett. 15(10) , 2685-8, (2005)

The development of a novel series of 4-aryl, 4-phenylsulfonyl cyclohexananone-derived gamma-secretase inhibitors for the potential treatment of Alzheimer's disease is described.

Synthesis and evaluation of [(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]cyclohexanes and 4-[(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]piperidines as DPP-4 inhibitors.

Bioorg. Med. Chem. Lett. 21 , 1880-1886, (2011)

A series of 4-amino cyclohexanes and 4-substituted piperidines were prepared and evaluated for inhibition of DPP-4. Analog 20q displayed both good DPP-4 potency and selectivity against other proteases...

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