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2,6-二甲基苯胺

2,6-二甲基苯胺用途

用作农药、医药中间体，用于制造甲霜灵、呋霜灵和利多卡因等

2,6-二甲基苯胺名称

[ CAS 号 ]:
87-62-7

[ 中文名 ]:
2,6-二甲基苯胺

[ 英文名 ]:
2,6-xylidine

[中文别名 ]:

[英文别名 ]:

o-Xylidine
2-Amino-1,3-xylene
2,6-dimethyl-aniline
Benzene, 2-amino-1,3-dimethyl-
1-amino-2,6-dimethybenzene
Benzenamine,2,6-dimethyl
2,6-xylidine
2,6-dimethylphenylamine
2,6-dimethylbenzeneamine
aniline, 2,6-dimethyl-

2,6-二甲基苯胺物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
217.9±0.0 °C at 760 mmHg

[ 熔点 ]:
10-12 °C(lit.)

[ 分子式 ]:
C₈H₁₁N

[ 分子量 ]:
121.180

[ 闪点 ]:
91.1±0.0 °C

[ 精确质量 ]:
121.089149

[ PSA ]:
26.02000

[ LogP ]:
1.86

[ 外观性状 ]:
无色至微红的黄色液体

[ 蒸汽压 ]:
0.1±0.4 mmHg at 25°C

[ 折射率 ]:
1.559

[ 储存条件 ]:
库房通风低温干燥,与酸类、氧化剂、食品添加剂分开存放

[ 水溶解性 ]:
7.5 g/L (20 ºC)

2,6-二甲基苯胺MSDS

2,6-二甲基苯胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ZE9275000

CHEMICAL NAME :: 2,6-Xylidine

CAS REGISTRY NUMBER :: 87-62-7

BEILSTEIN REFERENCE NO. :: 0636332

LAST UPDATED :: 199710

DATA ITEMS CITED :: 19

MOLECULAR FORMULA :: C8-H11-N

MOLECULAR WEIGHT :: 121.20

WISWESSER LINE NOTATION :: ZR B1 F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 840 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - cyanosis Blood - changes in spleen

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 707 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3150 mg/kg/20D-C

TOXIC EFFECTS :: Blood - changes in spleen

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6200 mg/kg/2W-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 13300 mg/kg/4W-I

TOXIC EFFECTS :: Liver - other changes Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 20150 mg/kg/13W-I

TOXIC EFFECTS :: Brain and Coverings - changes in brain weight Liver - changes in liver weight Blood - changes in other cell count (unspecified)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 107 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Endocrine - tumors

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 301 mg/L

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 10(Suppl 10),1,1987 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 57,323,1993 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 57,323,1993 IARC Cancer Review:Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 57,323,1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7951 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 4354 (estimated) No. of Female Employees: 729 (estimated)

2,6-二甲基苯胺安全信息

[ 符号 ]:

GHS07, GHS08, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302 + H312 + H332-H315-H335-H351-H411

[ 警示性声明 ]:
P261-P273-P280

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn:Harmful;N:Dangerousfortheenvironment;

[ 风险声明 (欧洲) ]:
R20/21/22;R37/38;R40;R51/53

[ 安全声明 (欧洲) ]:
S23-S25-S36/37-S61

[ 危险品运输编码 ]:
UN 1711 6.1/PG 2

[ WGK德国 ]:
2

[ RTECS号 ]:
ZE9275000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1

[ 海关编码 ]:
29214910

2,6-二甲基苯胺合成路线

2,6-二甲基苯胺上下游产品

2,6-二甲基苯胺上游产品

2,6-二甲基苯胺下游产品

2,6-二甲基苯胺制备

1.该产品的合成路线主要有2,6-二甲基苯酚氨解法、邻甲基苯胺烷基化法、苯胺甲基化法、间二甲苯双磺化硝化法和间二甲苯硝化还原法等。

2,6-二甲基苯胺海关

[ 海关编码 ]: 2921430090

[ 中文概述 ]:
2921430090 甲苯胺及其衍生物以及它们的盐. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 原产地证据文件及编号(例附原产地证书, 原产于欧盟的

[ Summary ]:
HS:2921430090 toluidines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

2,6-二甲基苯胺文献

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J. Pharm. Sci. 104 , 3101-19, (2015)

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Concentrations of dimethylaniline and other metabolites in milk and tissues of dairy cows treated with lidocaine.

Food Addit. Contam. Part A. Chem. Anal. Control. Expo. Risk Assess. 32 , 1256-64, (2015)

Lidocaine is a topical anaesthetic drug used in dairy cows for laparotomy (caesarean section, abomasal displacement). Because there are no registered drugs for this indication, it can be applied under...

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