邻硝基甲苯

邻硝基甲苯用途

【用途一】
用作染料、农药的中间体，也用于生产涂料、塑料和医药等
【用途二】
主要用于生产邻甲苯胺、联甲苯胺，是染料、涂料、塑料和医药的重要原料。在医药工业用于生产硝苯吡啶、痛惊宁、丙咪嗪盐酸盐、溴已胺盐酸盐、双氯苯唑青霉素钠等。
【用途三】
主要用于生产邻甲苯胺、联甲苯胺，是染料、涂料、塑料和医药的重要原料。在医药工业用于生产硝苯吡啶、痛惊宁、丙咪嗪盐酸盐、溴已胺盐酸盐、双氯苯唑青霉素钠等。用于ICP-AES、AAS、AFS、ICP-MS、离子色谱等。滴定分析用标准溶液。

邻硝基甲苯名称

[ CAS 号 ]:
88-72-2

[ 中文名 ]:
2-硝基甲苯

[ 英文名 ]:
2-Nitrotoluene

[中文别名 ]:

[英文别名 ]:

mononitrotoluene
2-Nitrotoluol
2-methylnitrobenzene
O-NITROTOLUENE
o-nitrotolueneu
ortho-nitrotoluene
o-itrotoluene
2-Nitrotoluene
o-nitrotoluol
o-nitro-toluen

邻硝基甲苯物理化学性质

[ 密度 ]:
1.163 g/mL at 25 °C(lit.)

[ 沸点 ]:
225 °C(lit.)

[ 熔点 ]:
-9 °C

[ 分子式 ]:
C₇H₇NO₂

[ 分子量 ]:
137.13600

[ 闪点 ]:
223 °F

[ 精确质量 ]:
137.04800

[ PSA ]:
45.82000

[ LogP ]:
2.42640

[ 外观性状 ]:
淡黄色至暗黄色-绿色液体

[ 折射率 ]:
n20/D 1.546(lit.)

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、食品添加剂分开存放

[ 稳定性 ]:
Stable. Combustible. Incompatible with oxidizing agents, strong bases, sulfuric acid, reducing agents, hydrogen, sodium.

[ 水溶解性 ]:
0.44 g/L (20 ºC)

邻硝基甲苯MSDS

详细MSDS(安全技术说明书)

邻硝基甲苯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XT3150000

CHEMICAL NAME :: Toluene, o-nitro-

CAS REGISTRY NUMBER :: 88-72-2

LAST UPDATED :: 199712

DATA ITEMS CITED :: 38

MOLECULAR FORMULA :: C7-H7-N-O2

MOLECULAR WEIGHT :: 137.15

WISWESSER LINE NOTATION :: WNR B1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 891 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 790 mg/m3

TOXIC EFFECTS :: Brain and Coverings - recordings from specific areas of CNS Liver - fatty liver degeneration Blood - methemoglobinemia-carboxyhemoglobin

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 970 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 328 mg/m3

TOXIC EFFECTS :: Brain and Coverings - recordings from specific areas of CNS Liver - fatty liver degeneration Blood - methemoglobinemia-carboxyhemoglobin

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1750 mg/kg

TOXIC EFFECTS :: Brain and Coverings - recordings from specific areas of CNS Liver - fatty liver degeneration Blood - methemoglobinemia-carboxyhemoglobin

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 32123 mg/kg/13W-C

TOXIC EFFECTS :: Liver - changes in liver weight Blood - changes in platelet count Related to Chronic Data - changes in testicular weight

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 54600 mg/kg/26W-C

TOXIC EFFECTS :: Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - changes in testicular weight

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 70343 mg/kg/13W-C

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - olfactory nerve change Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8400 mg/kg/14D-I

TOXIC EFFECTS :: Blood - changes in other cell count (unspecified)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 54600 mg/kg/26W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Reproductive - Tumorigenic effects - other reproductive system tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 32123 mg/kg

SEX/DURATION :: male 13 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 69154 mg/kg

SEX/DURATION :: female 13 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - menstrual cycle changes or disorders

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 140 gm/kg

SEX/DURATION :: male 13 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

TYPE OF TEST :: DNA adduct

TYPE OF TEST :: Unscheduled DNA synthesis

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 10(Suppl 10),1,1987 *** REVIEWS *** ACGIH TLV-TWA 11 mg/m3 (2 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 65,409,1996 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 65,409,1996 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 65,409,1996 *** U.S. STANDARDS AND REGULATIONS *** OSHA PEL (Gen Indu):8H TWA 5 ppm (30 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 5 ppm (30 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 5 ppm (30 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 5 ppm (30 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 2 ppm (11 mg/m3);Skin JAN 1993 OEL-BELGIUM:TWA 2 ppm (11 mg/m3);Skin JAN 1993 OEL-DENMARK:TWA 2 ppm (12 mg/m3);Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO o-NITROTOLUENE-air:10H TWA 2 ppm (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81910 No. of Facilities: 20 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 285 (estimated)

邻硝基甲苯安全信息

[ 符号 ]:

GHS07, GHS08, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H340-H350-H361-H411

[ 警示性声明 ]:
P201-P273-P281-P308 + P313

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
T:Toxic;N:Dangerousfortheenvironment;

[ 风险声明 (欧洲) ]:
R22;R45;R46;R51/53;R62

[ 安全声明 (欧洲) ]:
S53-S45-S61-S27-S16

[ 危险品运输编码 ]:
UN 1664 6.1/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
XT3150000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1

[ 海关编码 ]:
29042000

邻硝基甲苯合成路线

详细合成路线

邻硝基甲苯上下游产品

邻硝基甲苯上游产品

邻硝基甲苯下游产品

邻硝基甲苯制备

甲苯用混酸硝化，生成混合的硝基甲苯，其中主要是邻硝基甲苯（约占三分之二）和对硝基甲苯（约占三分之一），经分离即得纯品。将甲苯加入反应器中，冷却至25℃以下，加入配好的混酸（即硝酸25-30%，硫酸55-58%及水20-21%），调节温度不得超过50℃。连续搅拌1-2h，然后静置6h，将生成的硝基甲苯分离，水洗，碱洗，除去未反应的甲苯及脂肪族化合物，粗制硝基甲苯产品的组成为邻硝基甲苯55-60%、间位2-5%，对位35-40%。收率90-95%。利用沸点与熔点的差别进行粗馏与晶析，可分离出各异构体。即先将粗制硝基甲苯经真空蒸馏，分离出大部分的邻硝基甲苯，残余的含有较多对硝基甲苯的馏分，再经减压蒸馏分出，经冷却，结晶，分离即得成品。高沸点的焦油状物质残存在蒸馏釜中。间位硝基甲苯含在分离对位体后的母液中，经反复积累后再精馏获得。邻位和对位硝基甲苯纯度可分别达98%和99%。国内工艺芝程为两锅串联，反应温度主锅为40-45℃，次锅为50-55℃。混酸的配制大致相仿，硝酸26-28%，硫酸56-57%，水16-18%。原料消耗定额：甲苯（98%）800kg/t、硝酸（98%）470kg/t、硫酸（92.5%）450kg/t、烧碱（42%）100kg/t。

邻硝基甲苯海关

[ 海关编码 ]: 2904202000

[ 中文概述 ]:
2904202000 硝基甲苯。监管条件:无。增值税率:17.0%。退税率:9.0%。最低关税:5.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2904202000 1-methyl-4-nitrobenzene。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%

邻硝基甲苯文献

Optimizations of packed sorbent and inlet temperature for large volume-direct aqueous injection-gas chromatography to determine high boiling volatile organic compounds in water.

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Many toxic man-made compounds have been introduced into the environment, and bacterial strains that are able to grow on them are ideal model systems for studying the evolution of metabolic pathways an...

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