2-Butanone, 4-[(nitrosomethyl)amino]- (9CI)

MOLECULAR FORMULA :

C5-H10-N2-O2

MOLECULAR WEIGHT :

130.17

WISWESSER LINE NOTATION :

ONN1&2V1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - hamster

DOSE/DURATION :

705 mg/kg

TOXIC EFFECTS :

Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Liver - other changes Kidney, Ureter, Bladder - other changes

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - hamster

DOSE/DURATION :

770 mg/kg/38W-I

TOXIC EFFECTS :

Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Gastrointestinal - colon tumors

TYPE OF TEST :

TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - hamster

DOSE/DURATION :

1377 mg/kg/34W-I

TOXIC EFFECTS :

Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Gastrointestinal - tumors

MUTATION DATA

TYPE OF TEST :

Mutation in mammalian somatic cells

TEST SYSTEM :

Rodent - hamster Lung

DOSE/DURATION :

700 umol/L

REFERENCE :

50EYAN "Structure-Activity Correlation as a Predictive Tool in Toxicology, Papers from a Symposium, 1981," Golberg, L., ed., Washington, DC, Hemisphere Pub. Corp., 1983 Volume(issue)/page/year: -,241,1983