邻氨基苯甲醚

邻氨基苯甲醚用途

【用途一】
用作染料、香料及医药中间体
【用途二】
用作测定汞的络合指示剂，偶氮染料中间体及杀菌剂
【用途三】
可用于制取偶氮染料、冰染染料及色酚AS-OL等染料以及愈创木酚、安痢平等医药。还可制取香兰素等。
【用途四】
显微微晶分析检验氰化物。络合指示剂滴定汞。有机合成。

邻氨基苯甲醚名称

[ CAS 号 ]:
90-04-0

[ 中文名 ]:
邻甲氧基苯胺

[ 英文名 ]:
2-Anisidine

[中文别名 ]:

[英文别名 ]:

Benzenamine, 2-methoxy-
2-Aminoanisole
o-Methoxyphenylamine
2-Anisidine
2-Methoxyaniline
1-amino-2-methoxy-benzene
o-Anisidine
ORTHO ANISIDINE
ortho-Methoxyphenylamine
2-methoxy-phenylamine

邻氨基苯甲醚物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
225.0±0.0 °C at 760 mmHg

[ 熔点 ]:
3-6 °C(lit.)

[ 分子式 ]:
C₇H₉NO

[ 分子量 ]:
123.152

[ 闪点 ]:
98.9±0.0 °C

[ 精确质量 ]:
123.068413

[ PSA ]:
35.25000

[ LogP ]:
1.09

[ 外观性状 ]:
淡黄色液体，暴露在空气中变成褐色

[ 蒸汽压 ]:
0.1±0.4 mmHg at 25°C

[ 折射率 ]:
1.555

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents, acid anhydrides, chloroformates, acids, some plastics, rubber. Air sensitive.

[ 水溶解性 ]:
13 g/L (20 ºC)

邻氨基苯甲醚MSDS

邻氨基苯甲醚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BZ5410000

CHEMICAL NAME :: o-Anisidine

CAS REGISTRY NUMBER :: 90-04-0

BEILSTEIN REFERENCE NO. :: 0386210

LAST UPDATED :: 199806

DATA ITEMS CITED :: 46

MOLECULAR FORMULA :: C7-H9-N-O

MOLECULAR WEIGHT :: 123.17

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1400 mg/kg

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes Blood - normocytic anemia Blood - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 870 mg/kg

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes Blood - normocytic anemia Blood - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 422 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: DNA damage

TYPE OF TEST :: DNA inhibition

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 10(Suppl 10),1,1987 *** REVIEWS *** ACGIH TLV-Animal carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 0.5 mg/m3 (0.1 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 27,63,1982 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 0.1 ppm (0.5 mg/m3) (skin) DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8. Volume(issue)/page/year: 3,10,1973 OSHA PEL (Gen Indu):8H TWA 0.5 mg/m3 (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 0.5 mg/m3 (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 0.5 mg/m3 (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 0.5 mg/m3 (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.1 ppm (0.5 mg/m3);Skin JAN 1993 OEL-AUSTRIA:TWA 0.1 ppm (0.5 mg/m3);Skin JAN 1993 OEL-BELGIUM:TWA 0.1 ppm (0.5 mg/m3);Skin JAN 1993 OEL-DENMARK:TWA 0.1 ppm (0.5 mg/m3);Skin JAN 1993 OEL-FINLAND:TWA 0.5 mg/m3;STEL 1.5 mg/m3;Skin;Carcinogen JAN 1993 OEL-FRANCE:TWA 0.1 ppm (0.5 mg/m3);Skin;Carcinogen JAN 1993 OEL-GERMANY:TWA 0.1 ppm (0.5 mg/m3);Skin JAN 1993 OEL-INDIA:TWA 0.1 ppm (0.5 mg/m3);Skin JAN 1993 OEL-THE NETHERLANDS:TWA 0.1 ppm (0.5 mg/m3);Skin JAN 1993 OEL-THE PHILIPPINES:TWA 0.5 mg/m3;Skin JAN 1993 OEL-RUSSIA:STEL 1 mg/m3;Skin JAN 1993 OEL-SWITZERLAND:TWA 0.1 ppm (0.5 mg/m3);STEL 0.2 ppm;Skin JAN 1993 OEL-UNITED KINGDOM:TWA 0.1 ppm (0.5 mg/m3);Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO o-ANISIDINE-air:10H CA TWA 0.5 mg/m3 (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X8302 No. of Facilities: 50 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 705 (estimated)

邻氨基苯甲醚安全信息

[ 符号 ]:

GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H311-H331-H341-H350

[ 警示性声明 ]:
P201-P261-P280-P301 + P310-P311

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
T:Toxic;

[ 风险声明 (欧洲) ]:
R23/24/25;R45;R68

[ 安全声明 (欧洲) ]:
S53-S45

[ 危险品运输编码 ]:
UN 2431 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
BZ5410000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2922199090

邻氨基苯甲醚合成路线

邻氨基苯甲醚上下游产品

邻氨基苯甲醚上游产品

邻氨基苯甲醚下游产品

邻氨基苯甲醚制备

1.由邻硝基苯甲醚还原而得，邻硝基苯甲醚可由邻硝基氯甲苯氧基化得到[91-23-6]，还原剂可采用硫化钠或铁粉。另外，也可由邻硝基苯酚经甲基化、还原来制取邻甲氧基苯胺。原料消耗定额：邻硝基氯苯1301kg/t、甲醇（98%）395kg/t、硫化钠（60%）1128kg/t、烧碱（96%）457kg/t。

2. 烟草：BU，14。

邻氨基苯甲醚海关

[ 海关编码 ]: 2922291000

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ Summary ]:
2922291000 4-methoxyaniline。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。Lowest tariff:6.5%。General tariff:30.0%

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