DL-扁桃酸

DL-扁桃酸用途

【用途一】
用作医药原料及中间体、染料中间体等
【用途二】
用作化学试剂，也用于有机合成
【用途三】
在医药工业可用于头孢羟唑、血管扩张药环扁桃酸酯、滴眼药羟苄唑、匹莫林等的中间体，也可作防腐剂。
【用途四】
锆的特殊试剂，测定铜，有机合成，杀菌剂。

DL-扁桃酸名称

[ CAS 号 ]:
90-64-2

[ 中文名 ]:
DL-苦杏仁酸

[ 英文名 ]:
DL-Mandelic acid

[中文别名 ]:

[英文别名 ]:

MFCD00064250
(+)-MANDELIC ACID
S-mandelic acid
(S)-Mandelate
(2S)-Hydroxy(phenyl)acetic acid
Mandelic acid
(+)-(S)-MANDELIC ACID
L-MANDELIC ACID
(S)-(+)-Mandelic acid
Benzeneacetic acid, α-hydroxy-, (S)-

DL-扁桃酸物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
321.8±22.0 °C at 760 mmHg

[ 熔点 ]:
119-121ºC(lit.)

[ 分子式 ]:
C₈H₈O₃

[ 分子量 ]:
152.147

[ 闪点 ]:
162.6±18.8 °C

[ 精确质量 ]:
152.047348

[ PSA ]:
57.53000

[ LogP ]:
0.92

[ 外观性状 ]:
白色晶体粉末

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.591

[ 储存条件 ]:
室温，避光

[ 水溶解性 ]:
150 g/L (20 ºC)

DL-扁桃酸MSDS

详细MSDS(安全技术说明书)

DL-扁桃酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OO6300000

CHEMICAL NAME :: Mandelic acid

CAS REGISTRY NUMBER :: 90-64-2

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C8-H8-O3

MOLECULAR WEIGHT :: 152.16

WISWESSER LINE NOTATION :: QYR&VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 64,79,1940

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 112,53,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EMSUA8 Experimental Medicine and Surgery. (Brooklyn, NY) V.1-29, 1943-71. Suspended. Volume(issue)/page/year: 4,223,1946

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Gastrointestinal - gastritis Gastrointestinal - ulceration or bleeding from stomach Liver - other changes

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 64,79,1940 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84432 No. of Facilities: 174 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1744 (estimated)

DL-扁桃酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn, Xi

[ 风险声明 (欧洲) ]:
R22;R36/37/38

[ 安全声明 (欧洲) ]:
22-24/25-37/39-26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
OO6300000

[ 海关编码 ]:
2918199090

DL-扁桃酸上下游产品

DL-扁桃酸上游产品

DL-扁桃酸下游产品

DL-扁桃酸制备

1.以异丙苯法制苯酚的副产苯乙酮为原料，氯化得二氯苯乙酮，然后与稀碱反应、水解，制得扁桃酸。2.以苯甲醛为原料。将氰化钠溶于水中，加入苯甲醛，搅拌下慢慢加入亚硫酸氢钠的饱和溶液，加至一半时，加入碎冰，将析出的苯羟乙腈层从水层中分出。水层用苯萃取，蒸出苯，剩余物与苯羟乙腈层合并，加入盐酸，在冷却下水解12h。然后加热除去过量的水和盐酸，冷却，滤出氯化铵和扁桃酸的混合物。把滤液蒸干，剩余物与以上固体合并，用冷苯洗涤。再用热苯提取，提取液经冷却、结晶、过滤、干燥，即得扁桃酸，收率50-52%。3.苯-乙醛酸法。4.苯乙酮法经与硝基苯在碱催化下反应制的。

2. 烟草：BU，26。

3.制法：

扁桃腈（3）：于装有搅拌器、温度计的反应瓶中，加入350mL水，氰化钠100g（2.0mol），搅拌溶解，加入新蒸馏过的苯甲醛（2）212g（2.0mol），剧烈搅拌下，加入约300mL饱和亚硫酸氢钠的溶液，控制反应温度在30～35℃，于20min加完（可用冰水浴冷却）。加完后再搅拌反应0.5h。静置后分出上层橘红色的油状物，得粗品扁桃腈（3）约220g。扁桃酸（1）：于装有搅拌器。温度计的反应瓶中，加入浓乙酸300mL，加热至60℃左右，分批加入上述扁桃腈（3）220g，（注意应在通风橱中进行反应）。待反应平稳后再于沸水浴加热反应2h。冷却，放置过夜。抽滤析出的固体（含氯化铵）。将固体物用乙醚^①提取两次（400mL×2），浓缩乙醚溶液至约1/3体积。冷却，析出固体。抽滤，干燥，得扁桃酸（1）135g。收率44%。用热水重结晶，mp121～123℃。也有报道mp118℃。注：①也可用热苯提取。

DL-扁桃酸海关

[ 海关编码 ]: 2918199090

[ 中文概述 ]:
HS: 2918199090. 其他含醇基但不含其他含氧基羧酸（包括其酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

DL-扁桃酸文献

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Meconium is the earliest stool of newborns. It is a complex matrix that reflects the degree of fetal exposure to environmental pollutants. To investigate exposure to xenobiotics, an analytical method ...

A chiral separation strategy for acidic drugs in capillary electrochromatography using both chlorinated and nonchlorinated polysaccharide-based selectors.

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A generic chiral separation strategy for the analysis of acidic compounds in CEC is proposed in completion of an earlier defined strategy for nonacidic compounds. The screening step of this strategy u...

Detection of autosomal dominant polycystic kidney disease by NMR spectroscopic fingerprinting of urine.

Kidney Int. 79(11) , 1244-53, (2011)

Autosomal dominant polycystic kidney disease (ADPKD) is a frequent cause of kidney failure; however, urinary biomarkers for the disease are lacking. In a step towards identifying such markers, we used...

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