Ipidacrine hydrochloride

Ipidacrine hydrochloride用途

Ipidacrine hydrochloride is a reversible acetylcholinesterase (AChE) inhibitor that directly stimulates impulse transmission in the central nervous system and neuromuscular synapses by blocking membrane potassium channels.

Ipidacrine hydrochloride名称

[ CAS 号 ]:
90043-86-0

[ 英文名 ]:
Ipidacrine hydrochloride

[英文别名 ]:

NIK 247
Ipidacrine hydrochloride
Amiridin

Ipidacrine hydrochloride物理化学性质

[ 沸点 ]:
368ºC at 760mmHg

[ 分子式 ]:
C₁₂H₁₇ClN₂

[ 分子量 ]:
224.73000

[ 闪点 ]:
204ºC

[ 精确质量 ]:
224.10800

[ PSA ]:
38.91000

[ LogP ]:
3.41450

[ 储存条件 ]:
库房通风低温干燥

Ipidacrine hydrochloride毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GY5925000

CHEMICAL NAME :: 1H-Cyclopenta(b)quinoline, 2,3,5,6,7,8-hexahydro-9-amino-, monohydrochloride, hydrate

CAS REGISTRY NUMBER :: 90043-86-0

LAST UPDATED :: 198508

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C12-H16-N2.Cl-H.H2-O

MOLECULAR WEIGHT :: 242.78

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 60 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BAXXDU British UK Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2125696

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 68 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BAXXDU British UK Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2125696

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 44 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BAXXDU British UK Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2125696

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 52 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BAXXDU British UK Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2125696

Ipidacrine hydrochloride安全信息

[ 海关编码 ]:
2933990090

Ipidacrine hydrochloride海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%