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吐温20

吐温20用途

聚山梨酯20是一种聚氧乙烯(POE)型非离子表面活性剂[1][2][3]。

吐温20名称

[ CAS 号 ]:
9005-64-5

[ 中文名 ]:
吐温20

[ 英文名 ]:
Tween 20

[中文别名 ]:

[英文别名 ]:

Polysorbate 40 (NF)
Polyoxyethylene (20) sorbitan monolaurate
polyoxyethylene sorbitan monolaurate
Tween.(TM). 20
Polysorbate (INN)
Tween 20
MDL 11,939
EINECS 500-018-3
Polysorbate 60 (NF)
Polysorbate

吐温20生物活性

[ 描述 ]:

聚山梨酯20是一种聚氧乙烯(POE)型非离子表面活性剂[1][2][3]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[体外研究]

添加聚山梨酯20可以改变木质素的表面性质,改变其疏水性、氢键能力和表面电荷,从而减少蛋白质的非生产性吸附[1]。将聚山梨酯20(0.35%-0.7%w/w)添加到0.05 mol/L pH 6.5的磷酸盐缓冲液中,可显著增加药物的表观溶解度,从0.8μg/ml甚至增加到353μg/ml,而在较低pH值或水中的效果则小得多(pH 4.5中为20μg/ml)。在pH值为6.5、含有0.7%聚山梨酯20的情况下,磷酸盐浓度(0.2 mol/l)增加,导致坎地沙坦-西来塞替尔的溶解度进一步增加至620μg/ml[2]。

[参考文献]

[1]. Yu-An Chen, et al. Evaluation of the action of Tween 20 non-ionic surfactant during enzymatic hydrolysis of lignocellulose: Pretreatment, hydrolysis conditions and lignin structure. Bioresour Technol. 2018 Dec;269:329-338.

[2]. Katarzyna Hoppe, et al. The effect of polysorbate 20 on solubility and stability of candesartan cilexetil in dissolution media. AAPS PharmSciTech. 2014 Oct;15(5):1116-25.

[3]. JustynaŁuczak, et al. Micelle formation of Tween 20 nonionic surfactant in imidazolium ionic liquids. Colloids and Surfaces A: Physicochemical and Engineering Aspects. Volume 471, 20 April 2015, Pages 26-37.

吐温20物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
695.8±55.0 °C at 760 mmHg

[ 分子式 ]:
C₂₆H₅₀O₁₀

[ 分子量 ]:
604.813

[ 闪点 ]:
207.1±25.0 °C

[ 精确质量 ]:
604.418640

[ PSA ]:
133.14000

[ LogP ]:
5.37

[ 外观性状 ]:
淡黄色油性液体

[ 蒸汽压 ]:
0.0±5.0 mmHg at 25°C

[ 折射率 ]:
1.502

[ 储存条件 ]:
0-6°C

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
100 g/L | 100 g/L

吐温20MSDS

详细MSDS(安全技术说明书)

吐温20毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TR7400000

CHEMICAL NAME :: Polysorbate 20

CAS REGISTRY NUMBER :: 9005-64-5

LAST UPDATED :: 199710

DATA ITEMS CITED :: 21

MOLECULAR FORMULA :: C58-H114-O26

MOLECULAR WEIGHT :: 1227.72

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Human

REFERENCE :: 85DKA8 "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977 Volume(issue)/page/year: -,127,1977 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 36700 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher information, see JFDSAZ. Volume(issue)/page/year: 21,348,1956

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3850 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 26,1581,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 770 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 26,1581,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >33 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 26,1581,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2640 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 26,1581,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1420 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year: 2,316,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 18 mL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher information, see JFDSAZ. Volume(issue)/page/year: 21,348,1956 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 832 gm/kg/59D-C

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Related to Chronic Data - death

REFERENCE :: ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.31- 1951- Volume(issue)/page/year: 34,249,1951

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 931 gm/kg/70D-C

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Liver - fatty liver degeneration Liver - other changes

REFERENCE :: ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.31- 1951- Volume(issue)/page/year: 34,249,1951

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2756 gm/kg/21W-C

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Kidney, Ureter, Bladder - other changes Blood - other changes

REFERENCE :: FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher information, see JFDSAZ. Volume(issue)/page/year: 21,348,1956

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 33250 gm/kg/95W-C

TOXIC EFFECTS :: Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 7,320,1965

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 3276 gm/kg/39W-C

TOXIC EFFECTS :: Gastrointestinal - other changes Liver - other changes Blood - changes in spleen

REFERENCE :: FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher information, see JFDSAZ. Volume(issue)/page/year: 21,348,1956 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 1 gm/kg

SEX/DURATION :: female 9 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: ZNCBDA Zeitschrift fuer Naturforschung, Section C: Biosciences. (Verlag der Zeitschrift fuer Naturforschung, Postfach 2645, D-7400 Tuebingen, Fed. Rep. Ger.) V.29- 1974- Volume(issue)/page/year: 36,904,1981

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 2500 mg/kg

SEX/DURATION :: female 9 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: ZNCBDA Zeitschrift fuer Naturforschung, Section C: Biosciences. (Verlag der Zeitschrift fuer Naturforschung, Postfach 2645, D-7400 Tuebingen, Fed. Rep. Ger.) V.29- 1974- Volume(issue)/page/year: 36,904,1981

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 1 gm/kg

SEX/DURATION :: female 9 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 26(3),19A,1982 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6874 No. of Facilities: 5475 (estimated) No. of Industries: 22 No. of Occupations: 48 No. of Employees: 161625 (estimated) No. of Female Employees: 125776 (estimated)

吐温20安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
22-36/37/38-37/38-41

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
TR7400000

[ 海关编码 ]:
34021300

吐温20制备

1.将1 mol斯盘20投入反应釜中，在搅拌下加50%液碱作催化剂，逐渐升温，减压脱水，把水脱尽后用氮气置换釜中的空气，驱净空气后升温至120℃开始通入20 mol环氧乙烷，反应温度维持在150～170℃，压力0.2～0.3 MPa。通完环氧乙烷后，冷却至80～90℃，将料液打入中和釜用冰醋酸中和，再用双氧水脱色，最后冷却脱色，最后冷却放料，包装即为成品。在甲醇钠(或乙醇钠)的催化下，在130～170℃时，在span-20中通入一定量的环氧乙烷发生加成反应得产品。

吐温20海关

[ 海关编码 ]: 34021300

吐温20文献

Pharmacological inhibition of p38 MAPK reduces tumor growth in patient-derived xenografts from colon tumors.

Oncotarget 6 , 8539-51, (2015)

Colorectal cancer is a major health problem and the second cause of cancer related death in western countries. Signaling pathways that control tissue homeostasis are often deregulated during tumorigen...

Pharmacogenomic and clinical data link non-pharmacokinetic metabolic dysregulation to drug side effect pathogenesis.

Nat. Commun. 6 , 7101, (2015)

Drug side effects cause a significant clinical and economic burden. However, mechanisms of drug action underlying side effect pathogenesis remain largely unknown. Here, we integrate pharmacogenomic an...

Interleukin-10 conjugated electrospun polycaprolactone (PCL) nanofibre scaffolds for promoting alternatively activated (M2) macrophages around the peripheral nerve in vivo.

J. Immunol. Methods 420 , 38-49, (2015)

Macrophages play a key role in tissue regeneration following peripheral nerve injury by preparing the surrounding parenchyma for regeneration, however, they can be damaging if the response is excessiv...

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