5'-核苷酸酶

5'-核苷酸酶用途

5'-核苷酸酶是一种对底物特异性不高的水解酶，可作用于多种核苷酸。由2个相同的亚单位组成，每个亚单位的分子量均为70kD，在细胞膜表面外部有疏水基和1个酶催化活性中心。广泛存在于人体肝脏和各种组织中，定位于细胞膜上，在肝内主要存在于胆小管和窦状隙膜内。

5'-核苷酸酶名称

[ CAS 号 ]:
9027-73-0

[ 中文名 ]:
5'-核苷酸酶

[ 英文名 ]:
5'-Nucleotidase

[英文别名 ]:

5'-Mononucleotidase
CD antigens, CD73
CD73
CD73 antigens
E.C. 3.1.3.5
EC 3.1.3.5
Ecto-5'-nucleotidase
Ectonucleotidase
Nucleotide phosphomonoesterase
Snake venom 5'-nucleotidase

5'-核苷酸酶生物活性

[ 描述 ]:

5′-核苷酸酶(CD73)是一种以胞外酶形式存在的固有膜糖蛋白。5′-核苷酸酶催化5-核苷酸水解为相应的核苷[1]。

[ 相关类别 ]:

研究领域 >> 代谢疾病

[参考文献]

[1]. Hyder MA, et al. Comparative Study of 5'-Nucleotidase Test in Various Liver Diseases. J Clin Diagn Res. 2016 Feb;10(2):BC01-3.

5'-核苷酸酶物理化学性质

[ 外观性状 ]:
lyophilized powder

[ 储存条件 ]:
−20°C

5'-核苷酸酶安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H319

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
36

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

5'-核苷酸酶文献

Initial characterization of the human central proteome.

BMC Syst. Biol. 5 , 17, (2011)

On the basis of large proteomics datasets measured from seven human cell lines we consider their intersection as an approximation of the human central proteome, which is the set of proteins ubiquitous...

A quantitative atlas of mitotic phosphorylation.

Proc. Natl. Acad. Sci. U. S. A. 105(31) , 10762-7, (2008)

The eukaryotic cell division cycle is characterized by a sequence of orderly and highly regulated events resulting in the duplication and separation of all cellular material into two newly formed daug...

Complete sequencing and characterization of 21,243 full-length human cDNAs.

Nat. Genet. 36 , 40-5, (2004)

As a base for human transcriptome and functional genomics, we created the "full-length long Japan" (FLJ) collection of sequenced human cDNAs. We determined the entire sequence of 21,243 selected clone...

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