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苋菜红

苋菜红用途

Amaranth是一种暗红色至紫色的偶氮染料, 用作食品染料和化妆品, Amaranth是一种阴离子染料, 可应用到天然和合成纤维, 皮革, 纸张, 及苯酚-甲醛树脂。

苋菜红名称

[ CAS 号 ]:
915-67-3

[ 中文名 ]:
酸性红 27

[ 英文名 ]:
Amaranth

[中文别名 ]:

[英文别名 ]:

Amaranth Extra
hidacid amaranth
l-rot3
FD & C Red No. 2
maple amaranth
Red dye No. 2
amaranth bpc
red no. 2
S-azo rubine
CI Food Red 9

苋菜红生物活性

[ 描述 ]:

Amaranth是一种暗红色至紫色的偶氮染料, 用作食品染料和化妆品, Amaranth是一种阴离子染料, 可应用到天然和合成纤维, 皮革, 纸张, 及苯酚-甲醛树脂。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

染料试剂

研究领域 >> 其他

[相关活性小分子]

苋菜红物理化学性质

[ 密度 ]:
1.5

[ 熔点 ]:
>300°C

[ 分子式 ]:
C₂₀H₁₁N₂Na₃O₁₀S₃

[ 分子量 ]:
604.473

[ 闪点 ]:
44ºC

[ 精确质量 ]:
603.926880

[ PSA ]:
241.69000

[ LogP ]:
6.06870

[ 外观性状 ]:
暗红色至紫色粉末

[ 储存条件 ]:
室温

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
50 g/L (20 ºC)

苋菜红MSDS

详细MSDS(安全技术说明书)

苋菜红毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QJ6550000

CHEMICAL NAME :: 2,7-Naphthalenedisulfonic acid, 3-hydroxy-4-((4-sulfo-1-naphthyl)azo)-, trisodium salt

CAS REGISTRY NUMBER :: 915-67-3

LAST UPDATED :: 199709

DATA ITEMS CITED :: 36

MOLECULAR FORMULA :: C20-H11-N2-O10-S3.3Na

MOLECULAR WEIGHT :: 604.48

WISWESSER LINE NOTATION :: L66J BSWQ ENUN- BL66J CQ DSWQ HSWQ &-NA- 3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 96550 ug/kg/28D-C

TOXIC EFFECTS :: Liver - changes in liver weight

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 680 gm/kg/14W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors Blood - lymphoma, including Hodgkin's disease

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1200 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Blood - lymphoma, including Hodgkin's disease

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1643 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 548 mg/kg

SEX/DURATION :: female 52 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - menstrual cycle changes or disorders

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 547 mg/kg

SEX/DURATION :: multigenerations

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive - Effects on Newborn - live birth index (measured after birth)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 33 mg/kg

SEX/DURATION :: female 1-22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 65 mg/kg

SEX/DURATION :: multigenerations

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 296 mg/kg

SEX/DURATION :: multigenerations

TOXIC EFFECTS :: Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 548 mg/kg

SEX/DURATION :: male 52 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 3528 ug/kg

SEX/DURATION :: male 4 week(s) pre-mating female 4 week(s) pre-mating - 3 week(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - behavioral

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 4550 uL/kg

SEX/DURATION :: male 4 week(s) pre-mating female 4 week(s) pre-mating - 2 week(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - other effects to embryo

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 4900 uL/kg

SEX/DURATION :: male 4 week(s) pre-mating female 4 week(s) pre-mating - 3 week(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - live birth index (measured after birth)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 12 mL/kg

SEX/DURATION :: male 4 week(s) pre-mating female 4 week(s) pre-mating - 4 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - behavioral

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 250 mg/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 16500 ug/kg

SEX/DURATION :: female 6-16 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 100 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 2 gm/L

REFERENCE :: GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971- Volume(issue)/page/year: 27,95,1981 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 8,41,1975 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 8,41,1975 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW ARVPAX Annual Review of Pharmacology. (Palo Alto, CA) V.1-15, 1961-75. For publisher information, see ARPTDI. Volume(issue)/page/year: 14,127,1974 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M2137 No. of Facilities: 1931 (estimated) No. of Industries: 9 No. of Occupations: 12 No. of Employees: 13075 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M2137 No. of Facilities: 2272 (estimated) No. of Industries: 12 No. of Occupations: 22 No. of Employees: 13792 (estimated) No. of Female Employees: 5645 (estimated)

苋菜红安全信息

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
36/37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
QJ6550000

苋菜红上下游产品

苋菜红上游产品

苋菜红下游产品

苋菜红制备

1. 苋菜红的制备
将1-萘胺-4-磺酸钠溶解于8～9倍量(质量)75～85℃的水，过滤，并冷却至0～5℃；加入原钠盐1.2～1.5倍量(质量)的盐酸，搅匀静置，析出细微的1-萘胺-4-磺酸结晶，再将其冷却至5℃以下；在3～5℃下缓缓加入1：2(质量)的亚硝酸钠溶液进行重氮化，得微黄色糊状重氮液，反应完毕后料液对刚果红试纸呈强酸性(显蓝色)。
将R酸钠(2-萘酚-3，6-二磺酸钠)溶解于9～10倍量(质量)60～65℃的水中，再加入部分碳酸钠(总量的1/5)，溶解后过滤，滤液投入反应釜内，然后加入其余的碳酸钠，搅拌溶解并冷却至5～8℃；再在10～15℃和Ph值为8时，缓缓加入重氮液进行偶合反应数小时。反应完毕后(2-萘酚-3，6-二磺酸钠略为过量)将溶液升温至50～60℃，加入精制氯化钠、搅拌，再使其自然冷却至室温，静置析出结晶。将结晶溶解于15倍量(质量)70℃的洁净水中，加入适量的碳酸钠，使溶液呈微碱性，过滤后加入精盐，搅拌并用盐酸调pH值至6.5~7.0，静置结晶、分离干燥得产品。 2. 苋菜红铝色淀的制备
由氯化铝、硫酸铝等的铝盐与碳酸钠等的碱类制取氢氧化铝，添加于苋菜红水溶液中，沉淀而得产品。

苋菜红文献

Evaluation of potential genotoxicity of five food dyes using the somatic mutation and recombination test.

Chemosphere 88(8) , 974-9, (2012)

In this study, different concentrations of five food dyes (amaranth, patent blue, carminic acid, indigotine and erythrosine) have been evaluated for genotoxicity in the Somatic Mutation and Recombinat...

Monoolein cubic phase containing acidic proteinoid: pH-dependent release.

Drug Dev. Ind. Pharm. 37(1) , 56-61, (2011)

Monoolein (MO) cubic phase containing acidic proteinoid was prepared for a pH-dependent release.The acidic proteinoid was prepared by a thermal-condensation reaction of Asp and Leu (9.85/0.15 in molar...

Genotoxicity assessment of amaranth and allura red using Saccharomyces cerevisiae.

Bull. Environ. Contam. Toxicol. 90(1) , 22-6, (2013)

Amaranth (E123) and Allura red (E129), very important food azo dyes used in food, drug, paper, cosmetic and textile industries, were assessed for their genotoxic potential through comet assay in yeast...

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苋菜红