2-(4-Benzylphenoxy)-N,N-diethylethylamine hydrochloride

[ 沸点 ]:
397ºC at 760 mmHg

[ 分子式 ]:
C₆H₁₂N₂NaO₁₂P₄Sm----

[ 分子量 ]:
603.97300

[ 闪点 ]:
116.8ºC

[ 精确质量 ]:
603.84600

[ PSA ]:
280.51000

[ LogP ]:
1.76460

详细MSDS(安全技术说明书)

[ 危险品运输编码 ]:
UN 3077 9 / PGIII

详细合成路线

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Enhancement of antitumour activity of cisplatin by N,N-diethyl-2-[4-(phenylmethyl)phenoxy] ethanamine. HCl in human ovarian cancer cells with intrinsic or acquired resistance to cisplatin.

Eur. J. Cancer 33(1) , 122-8, (1997)

This study was designed to the elucidate sensitising effects of the intracellular histamine antagonist, N,N-diethyl-2[4-(phenylmethyl)phenoxy] ethanamine HCl (DPPE) on the antitumour activity of cis-d...

Effect of alpha-FMH and DPPE on colony-forming properties of human peripheral progenitor cells.

Curr. Med. Chem. 9(14) , 1349-57, (2002)

Endogenous histamine regulates the haematopoiesis. Histidine decarboxylase inhibitor decreases the histamine level, and its intracellular antagonist decreases the histamine effect. The effect of histi...

Effects of tesmilifene, a substrate of CYP3A and an inhibitor of P-glycoprotein, on the pharmacokinetics of intravenous and oral docetaxel in rats.

J. Pharm. Pharmacol. 62(8) , 1084-8, (2010)

It has been reported that docetaxel is a P-glycoprotein substrate and is metabolized via the cytochrome P450 (CYP) 3A subfamily in rats. Tesmilifene is a substrate of the CYP3A subfamily and is an inh...

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