2-氯苯胺

2-氯苯胺用途

【用途一】
用作农药、医药、染料和合成树脂的中间体
【用途二】
用作染料中间体，也用于有机合成
【用途三】
邻氯苯胺是除草剂绿磺隆的原料，也是重要的染料中间体。
【用途四】
该品为冰染染料色基，亦可作为偶氮染料的重氮组分，用于生产酸性黑、酸性蓝及有机色淀水固黄R、永固红FR、汉沙黄HR等。并可用于制取医药、农药、聚氨酯树脂的交联剂甲基双氯苯胺。
【用途五】
用作染料中间体、溶剂、防霉剂及试剂。

2-氯苯胺名称

[ CAS 号 ]:
95-51-2

[ 中文名 ]:
邻氯苯胺

[ 英文名 ]:
2-Chloroaniline

[中文别名 ]:

[英文别名 ]:

Benzenamine, 2-chloro-
1-Chloro-2-aminobenzene
2-chlorophenylamine
2-chloro-aniline
2-Chloroanline
OCA
O-CHLOROANILINE D
2-CHLOROBENZAMINE
BENZENAMINE,2-CHLORO-
MFCD00007656

2-氯苯胺物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
208.8±0.0 °C at 760 mmHg

[ 熔点 ]:
0-3 °C

[ 分子式 ]:
C₆H₆ClN

[ 分子量 ]:
127.572

[ 闪点 ]:
97.8±0.0 °C

[ 精确质量 ]:
127.018875

[ PSA ]:
26.02000

[ LogP ]:
1.91

[ 外观性状 ]:
透明琥珀色液体

[ 蒸汽压 ]:
0.2±0.4 mmHg at 25°C

[ 折射率 ]:
1.598

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、酸类、食品添加剂分开存放

[ 水溶解性 ]:
5.13 g/L (20 ºC)

2-氯苯胺MSDS

2-氯苯胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BX0525000

CHEMICAL NAME :: Aniline, o-chloro-

CAS REGISTRY NUMBER :: 95-51-2

LAST UPDATED :: 199712

DATA ITEMS CITED :: 18

MOLECULAR FORMULA :: C6-H6-Cl-N

MOLECULAR WEIGHT :: 127.58

WISWESSER LINE NOTATION :: ZR BG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 256 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 222 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 310 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - body temperature decrease

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 14560 mg/kg/13W-I

TOXIC EFFECTS :: Endocrine - changes in spleen weight Blood - pigmented or nucleated red blood cells Blood - methemoglobinemia-carboxyhemoglobin

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 14560 mg/kg/13W-I

TOXIC EFFECTS :: Endocrine - changes in spleen weight Blood - pigmented or nucleated red blood cells Blood - methemoglobinemia-carboxyhemoglobin

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 600 ug/L

REFERENCE :: BLFSBY Basic Life Sciences. (Plenum Pub. Corp., 223 Spring St., New York, NY 10003) V.1- 1973- Volume(issue)/page/year: 39,359,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83962 No. of Facilities: 38 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 18138 (estimated)

2-氯苯胺安全信息

[ 符号 ]:

GHS06, GHS08, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301 + H311 + H331-H319-H373-H410

[ 警示性声明 ]:
P261-P273-P280-P301 + P310 + P330-P403 + P233

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
T:Toxic;N:Dangerousfortheenvironment;

[ 风险声明 (欧洲) ]:
R23/24/25;R33;R50/53

[ 安全声明 (欧洲) ]:
S28-S36/37-S45-S60-S61-S28A

[ 危险品运输编码 ]:
UN 2019 6.1/PG 2

[ WGK德国 ]:
2

[ RTECS号 ]:
BX0525000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2921420090

2-氯苯胺合成路线

2-氯苯胺上下游产品

2-氯苯胺上游产品

2-氯苯胺下游产品

2-氯苯胺制备

1、由邻硝基氯苯还原而得：在盐酸介质中用铁粉还原，回流6-8h，经水蒸汽蒸馏、减压蒸馏得成品。也可以在甲酸存在下进行铁粉还原：在10m3的铸铁还原釜中加入2m3沸水，然后加入邻硝基氯苯100kg、甲酸15kg、铁粉1.5t，进行还原反应。在17-20h内分次加入4t邻硝基氯苯。其间，在还原反应进行到一刻钟时，加入1t邻硝基氯苯，同时加入铁粉1.5t和甲酸15kg。如果反应缓慢，可再加入铁粉1t。反应完成后，静置，分离出胺层，再静置，使铁沉淀，铁渣用水蒸汽蒸馏出胺。将粗品减压蒸馏，得邻氯苯胺3160kg，收率95%。原料消耗定额：邻硝基氯苯1300kg/t、铁粉（90%）1450kg/t、盐酸（37%） 380kg/t。

2、其制备方法是用邻氯硝基苯与铁屑、稀盐酸和水回流6～8h，蒸馏得粗品，再蒸馏得成品。
或者用催化加氢的方法，也就是以邻氯硝基苯为原料，在催化剂存在下加氢而制得成品。

精制方法：邻氯苯胺是由邻氯硝基苯还原，再经真空蒸馏而得。若含有对位异构体，可用等量的硫酸溶解，再进行水蒸气蒸馏。对位异构体以硫酸盐的形式残留下来而达到分离的目的。也可以将其溶解在10%的热盐酸中，冷却后邻位异构体呈盐酸盐结晶析出。

2-氯苯胺海关

[ 海关编码 ]: 2921420090

[ 中文概述 ]:
2921420090 其他苯胺衍生物及其盐. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
HS:2921420090 aniline derivatives and their salts VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

2-氯苯胺文献

Optimizations of packed sorbent and inlet temperature for large volume-direct aqueous injection-gas chromatography to determine high boiling volatile organic compounds in water.

J. Chromatogr. A. 1356 , 221-9, (2014)

For the expanded application area, fast trace analysis of certain high boiling point (i.e., 150-250 °C) volatile organic compounds (HVOCs) in water, a large volume-direct aqueous injection-gas chromat...

Biodegradation of 2-chloroaniline, 3-chloroaniline, and 4-chloroaniline by a novel strain Delftia tsuruhatensis H1.

J. Hazard. Mater. 179(1-3) , 875-82, (2010)

A new strain Delftia tsuruhatensis H1 able to degrade several chloroanilines (CAs) as individual compounds or a mixture was isolated from a CA-degrading mixed bacterial culture. The isolated strain co...

Biodegradability of chlorinated anilines in waters.

Biomed. Environ. Sci. 20(2) , 141-5, (2007)

To identify the bacteria tolerating chlorinated anilines and to study the biodegradability of o-chloroaniline and its coexistent compounds.Microbial community of complex bacteria was identified by pla...

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