PQ1 Succinate

PQ1 Succinate is a gap junction enhancer. It acts by restoring GJIC and increasing connexin expression in breast cancer cell lines while not affecting normal mammary cells.

[ 分子式 ]:
C₂₅H₂₈F₃N₃O₆

[ 分子量 ]:
523.502

[ 精确质量 ]:
523.192993

[ 危险品运输编码 ]:
NONH for all modes of transport

Gap Junction Enhancer Potentiates Cytotoxicity of Cisplatin in Breast Cancer Cells.

J. Cancer Sci. Ther. 4(11) , 371-378, (2012)

Cisplatin is one of the most widely used anti-cancer drugs due to its ability to damage DNA and induce apoptosis. However, increasing reports of side effects and drug resistance indicate the limitatio...

PQ1, a quinoline derivative, induces apoptosis in T47D breast cancer cells through activation of caspase-8 and caspase-9.

Apoptosis 18(9) , 1071-82, (2013)

Apoptosis, a programmed cell death, is an important control mechanism of cell homeostasis. Deficiency in apoptosis is one of the key features of cancer cells, allowing cells to escape from death. Acti...

The effect of the PQ1 anti-breast cancer agent on normal tissues.

Anticancer Drugs 23(9) , 897-905, (2012)

Gap junctions are intercellular channels connecting adjacent cells, allowing cells to transport small molecules. The loss of gap junctional intercellular communication (GJIC) is one of the important h...

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