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氯碘二碘

氯碘二碘用途

氯磺胺(二碘)是一种有效的烟碱型乙酰胆碱受体(nAChR)拮抗剂和神经节阻滞剂。氯磺胺以一种有效、持久和药理学选择性的方式对抗尼古丁的某些中枢作用[1]。

氯碘二碘名称

[ CAS 号 ]:
96750-66-2

[ 中文名 ]:
氯碘二碘

[ 英文名 ]:
Chlorisondamine diiodide

[英文别名 ]:

chlorisondamine iodide

氯碘二碘生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> 胆碱受体

信号通路 >> 神经信号通路 >> 胆碱受体

研究领域 >> 神经疾病

[ 靶点 ]

nAChR[1]

[体内研究]

氯磺胺(0.2、1.0、5.0μg；IV；单次剂量)在1周和2周时以剂量依赖性方式拮抗尼古丁对垂直活动(0-20min)的抑制作用【1】。动物模型：大鼠(尼古丁0.4 mg/kg,皮下注射一次)[1]剂量：0.2、1.0、5.0μg给药：IV；单次给药结果：1周和2周时,以剂量依赖性的方式拮抗尼古丁对垂直活动(0-20min)的抑制作用。

[参考文献]

[1]. Clarke PB. Chronic central nicotinic blockade after a single administration of the bisquaternary ganglion-blocking drug chlorisondamine. Br J Pharmacol. 1984;83(2):527-535. doi:10.1111/j.1476-5381.1984.tb16517.x

[2]. Clarke PB, et al. The pharmacology of the nicotinic antagonist, chlorisondamine, investigated in rat brain and autonomic ganglion. Br J Pharmacol. 1994 Feb;111(2):397-405.

[3]. Clarke PB. Chronic central nicotinic blockade after a single administration of the bisquaternary ganglion-blocking drug chlorisondamine. Br J Pharmacol. 1984;83(2):527-535. doi:10.1111/j.1476-5381.1984.tb16517.x

氯碘二碘物理化学性质

[ 分子式 ]:
C₁₄H₂₀Cl₄I₂N₂

[ 分子量 ]:
611.94

[ 精确质量 ]:
609.84700

[ 储存条件 ]:
-20°C，密闭，干燥

氯碘二碘MSDS

氯碘二碘安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H400

[ 警示性声明 ]:
P273

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;N: Dangerous for the environment;

[ 风险声明 (欧洲) ]:
22-50

[ 安全声明 (欧洲) ]:
60-61

[ 危险品运输编码 ]:
UN 3077 9 / PGIII

[ 海关编码 ]:
2933990090

氯碘二碘合成路线

氯碘二碘上下游产品

氯碘二碘上游产品

氯碘二碘下游产品

氯碘二碘海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

氯碘二碘文献

Cardiovascular afferents cause the release of 5-HT in the nucleus tractus solitarii; this release is regulated by the low- (PMAT) not the high-affinity transporter (SERT).

J. Physiol. 593(7) , 1715-29, (2015)

The nucleus tractus solitarii (NTS) integrates inputs from cardiovascular afferents and thus is crucial for cardiovascular homeostasis. These afferents primarily release glutamate, although 5-HT has a...

Effects of nicotine and chlorisondamine on cerebral glucose utilization in immobilized and freely-moving rats.

Br. J. Pharmacol. 129 , 147-155, (2000)

Chlorisondamine blocks central nicotinic receptors for many weeks via an unknown mechanism. Intracerebroventricular administration of [(3)H]-chlorisondamine in rats results in an anatomically restrict...

Modulation of neuronal nicotinic acetylcholine receptors by halothane in rat cortical neurons.

Mol. Pharmacol. 59 , 732-743, (2001)

Inhalational general anesthetics have recently been shown to inhibit neuronal nicotinic acetylcholine (ACh) receptors (nnAChRs) expressed in Xenopus laevis oocytes and in molluscan neurons. However, d...

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