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醋酸己酰胺

醋酸己酰胺用途

Acetohexamide是第一代磺脲类药物用于治疗2型糖尿病；刺激胰腺分泌胰岛素。

醋酸己酰胺名称

[ CAS 号 ]:
968-81-0

[ 中文名 ]:
乙酸己脲

[ 英文名 ]:
Acetohexamide

[中文别名 ]:

[英文别名 ]:

Metaglucina
Gamadiabet
1-(4-acetylphenyl)sulfonyl-3-cyclohexylurea
MFCD00072156
acetoxehamide
Acetohexamidum
Hypoglicil
Dimelin
Acetohexamid
EINECS 213-530-4

醋酸己酰胺生物活性

[ 描述 ]:

Acetohexamide是第一代磺脲类药物用于治疗2型糖尿病；刺激胰腺分泌胰岛素。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 代谢疾病

[相关活性小分子]

醋酸己酰胺物理化学性质

[ 密度 ]:
1.3g/cm3

[ 熔点 ]:
188-190° (GB 912789); mp 175-177° (Marshall)

[ 分子式 ]:
C₁₅H₂₀N₂O₄S

[ 分子量 ]:
324.39500

[ 精确质量 ]:
324.11400

[ PSA ]:
100.72000

[ LogP ]:
4.07240

[ 外观性状 ]:
solid | white

[ 折射率 ]:
1.581

[ 储存条件 ]:
库房通风低温干燥

[ 水溶解性 ]:
DMSO: ~45 mg/mL

醋酸己酰胺MSDS

详细MSDS(安全技术说明书)

醋酸己酰胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YR7350000

CHEMICAL NAME :: Urea, 1-((p-acetylphenyl)sulfonyl)-3-cyclohexyl-

CAS REGISTRY NUMBER :: 968-81-0

LAST UPDATED :: 199806

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C15-H20-N2-O4-S

MOLECULAR WEIGHT :: 324.43

WISWESSER LINE NOTATION :: L6TJ AMVMSWR DV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,34,1995

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,18,1982 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

DOSE :: 900 mg/kg

SEX/DURATION :: female 26-39 week(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - stillbirth

REFERENCE :: BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 2,187,1964 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83998 No. of Facilities: 33 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 627 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83998 No. of Facilities: 43 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 1626 (estimated) No. of Female Employees: 833 (estimated)

醋酸己酰胺安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
YR7350000

[ 海关编码 ]:
2935009090

醋酸己酰胺上下游产品

醋酸己酰胺上游产品

醋酸己酰胺下游产品

醋酸己酰胺制备

先由对氨基乙酰苯制取对乙酰苯磺酰胺，再继续与环已基异氰酸盐反应，得到醋磺环已脲。

醋酸己酰胺海关

[ 海关编码 ]: 2935009090

[ 中文概述 ]:
2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:35.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

醋酸己酰胺文献

Therapeutic targeting of BRCA1-mutated breast cancers with agents that activate DNA repair.

Cancer Res. 74(21) , 6205-15, (2014)

Cancers due to germline mutations in the BRCA1 gene tend to lack targets for approved chemoprevention agents. This study aimed at a targeted chemoprevention strategy for BRCA1-associated malignancies....

Analysis of free drug fractions by ultrafast affinity extraction: interactions of sulfonylurea drugs with normal or glycated human serum albumin.

J. Chromatogr. A. 1371 , 82-9, (2014)

Ultrafast affinity extraction and a multi-dimensional affinity system were developed for measuring free drug fractions at therapeutic levels. This approach was used to compare the free fractions and g...

CURRENT THERAPEUTICS. CCII. ACETOHEXAMIDE.

Practitioner 193 , 555-60, (1964)

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