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1-苯乙胺

1-苯乙胺用途

【用途一】
用作医药中间体
【用途二】
磷霉素的中间体。是一种拆分剂、手性合成的中间体。

1-苯乙胺名称

[ CAS 号 ]:
98-84-0

[ 中文名 ]:
1-苯乙胺

[ 英文名 ]:
(S)-(-)-1-Phenylethylamine

[中文别名 ]:

α-甲基苯甲胺

[英文别名 ]:

(−)-α-Methylbenzylamine
(S)-(−)-1-Phenylethylamine
(S)-(-)-α-Methylbenzylamine
phenyl-1ethylamine
1-Phenylethylamine
Benzenemethanamine, α-methyl-, (αS)-
(1S)-1-Phenylethanamine
S-α-Methylbenzylamine
1-phenyl-ethanamin
S-(-)-α-Phenylethylamine

1-苯乙胺物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
183.0±9.0 °C at 760 mmHg

[ 熔点 ]:
-65ºC

[ 分子式 ]:
C₈H₁₁N

[ 分子量 ]:
121.180

[ 闪点 ]:
79.4±0.0 °C

[ 精确质量 ]:
121.089149

[ PSA ]:
26.02000

[ LogP ]:
1.44

[ 蒸汽压 ]:
0.8±0.3 mmHg at 25°C

[ 折射率 ]:
1.533

[ 储存条件 ]:
库房通风低温干燥

1-苯乙胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DP5775000

CHEMICAL NAME :: Benzylamine, alpha-methyl-

CAS REGISTRY NUMBER :: 98-84-0

LAST UPDATED :: 199806

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C8-H11-N

MOLECULAR WEIGHT :: 121.20

WISWESSER LINE NOTATION :: 1M1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 940 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU. Volume(issue)/page/year: 4,119,1951

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 560 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 6,263,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 240 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 6,263,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 780 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU. Volume(issue)/page/year: 4,119,1951

1-苯乙胺安全信息

[ 危害码 (欧洲) ]:
C:Corrosive;

[ 风险声明 (欧洲) ]:
R21/22;R34

[ 安全声明 (欧洲) ]:
S26-S28-S36/37/39-S45

[ 危险品运输编码 ]:
UN 2735 8/PG 2

[ WGK德国 ]:
1

[ 包装等级 ]:
III

1-苯乙胺合成路线

详细合成路线

1-苯乙胺上下游产品

1-苯乙胺上游产品

1-苯乙胺下游产品

1-苯乙胺制备

1.由苯乙酮在高压催化氨存在下，用氢还原制得。工艺过程为：向2L高压釜内放入纯苯乙酮，阮尼镍和液氨，使混合物在150℃、34.5~24.1MPa压力下氢化，反应进行到不再吸收氢为止；将高压斧冷却，放氨和滤出催化剂。再将混合物放入冰浴冷却，用浓盐酸酸化至刚果红试纸呈酸性反应、除去过量苯乙酮；然后将剩余物放入烧瓶中的固体氢氧化钠上，经冷却即析出胺；再经苯提取、固体氢氧化钠干燥、蒸馏去苯；最后经减压蒸馏。收集80~81℃（2.4kPa）馏分即得成品。