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上海化源世纪贸易有限公司
上海市上海市普陀区
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纯度：98.0%
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上海脉铂医药科技有限公司
上海市上海市嘉定区
产品名：Dihydrotestosterone(DHT)
纯度：98.0%
规格：25mg/100mg/1g/1g
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江西瑞威尔生物科技有限公司
江西省吉安市峡江县
产品名：雄诺龙
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西安康诺化工有限公司
陕西省西安市雁塔区
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武汉壹加壹生物科技有限公司
湖北省武汉市江夏区
产品名：5α-二氢睾酮
纯度：98.0%
规格：1g
联系人：刘经理
联系电话：16602739303

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521-18-6生产厂家

521-18-6

521-18-6结构式

常用中文名：雄诺龙
常用英文名：Stanolone
CAS号：521-18-6
分子式：C₁₉H₃₀O₂
分子量：290.440
相关类别：分析化学标准品标准物质
发布时间：2018-06-01 08:00:00
更新时间：2024-01-02 19:09:47
雄激素类药

化源商城直购

中文名	5α-二氢睾酮
英文名	17β-hydroxy-5α-androstan-3-one
中文别名	雄诺龙
英文别名	Stanolone EINECS 208-307-3 Anaboleen 17β-Hydroxy-5α-androstane-3-one Androlone dihydrotestosterone Anabolex (5a,17b)-17-Hydroxyandrostan-3-one 5α-Dihydrotestosterone Stanorone 5α dihydrotestosterone Androstanolone DHT [14C]-Dihydrotestosterone Androstan-3-one, 17-hydroxy-, (5α,17β)- 5α-Androstan-3-one, 17β-hydroxy- [3H]-Dihydrotestosterone 17beta-hydroxy-5alpha-androstan-3-one Andractim 17β-hydroxy-5α-androstan-3-one Androstan-17b-ol-3-one Stanaprol 4-dihydrotestosterone Neodrol (5α,17β)-17-Hydroxyandrostan-3-one 5a-Dihydrotestosterone Protona Stanolon Anaprotin MFCD00003667

密度	1.1±0.1 g/cm3
沸点	413.1±38.0 °C at 760 mmHg
熔点	178-183 °C
分子式	C₁₉H₃₀O₂
分子量	290.440
闪点	176.4±19.4 °C
精确质量	290.224579
PSA	37.30000
LogP	3.75
蒸汽压	0.0±2.2 mmHg at 25°C
折射率	1.536
储存条件	本品应密封于阴凉干燥处保存。
稳定性	按规格使用和贮存，不会发生分解，避免与氧化物接触
分子结构	1、摩尔折射率：83.49 2、摩尔体积（m³/mol）：267.6 3、等张比容（90.2K）：677.7 4、表面张力（dyne/cm）：41.1 5、极化率（10^-24cm³）：33.10
计算化学	1、疏水参数计算参考值（XlogP）：3.7 2、氢键供体数量：1 3、氢键受体数量：2 4、可旋转化学键数量：0 5、互变异构体数量：3 6、拓扑分子极性表面积（TPSA）：37.3 7、重原子数量：21 8、表面电荷：0 9、复杂度：459 10、同位素原子数量：0 11、确定原子立构中心数量：7 12、不确定原子立构中心数量：0 13、确定化学键立构中心数量：0 14、不确定化学键立构中心数量：0 15、共价键单元数量：1
更多	1. 性状：结晶。一种促蛋白质合成的甾类化合物。 2. 密度（g/mL,25/4℃）：未确定 3. 相对蒸汽密度（g/mL,空气=1）：未确定 4. 熔点（ºC）：181 5. 沸点（ºC,常压）：未确定 6. 沸点（ºC,5.2kPa）：未确定 7. 折射率：未确定 8. 闪点（ºC）：未确定 9. 比旋光度（º）：－32.4°（乙醇中） 10. 自燃点或引燃温度（ºC）：未确定 11. 蒸气压（kPa,25ºC）：未确定 12. 饱和蒸气压（kPa,60ºC）：未确定 13. 燃烧热（KJ/mol）：未确定 14. 临界温度（ºC）：未确定 15. 临界压力（KPa）：未确定 16. 油水（辛醇/水）分配系数的对数值：未确定 17. 爆炸上限（%,V/V）：未确定 18. 爆炸下限（%,V/V）：未确定 19. 溶解性：溶于丙酮、乙醚、乙醇、乙酸乙酯，几乎不溶于水。

生态学数据:

该物质对环境可能有危害，对水体应给予特别注意。

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BV8052000

CHEMICAL NAME :: 5-alpha-Androstan-3-one, 17-beta-hydroxy-

CAS REGISTRY NUMBER :: 521-18-6

LAST UPDATED :: 199206

DATA ITEMS CITED :: 19

MOLECULAR FORMULA :: C19-H30-O2

MOLECULAR WEIGHT :: 290.49

WISWESSER LINE NOTATION :: L E5 B666 OVTJ A1 E1 FQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 17500 ug/kg

SEX/DURATION :: female 35 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 160 mg/kg

SEX/DURATION :: female 14-21 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - urogenital system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 1400 ug/kg

SEX/DURATION :: female 14 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina Reproductive - Fertility - other measures of fertility

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 700 ug/kg

SEX/DURATION :: female 14 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - ovaries, fallopian tubes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 80 mg/kg

SEX/DURATION :: female 13-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - skin and skin appendages Reproductive - Specific Developmental Abnormalities - urogenital system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Parenteral

DOSE :: 2500 ug/kg

SEX/DURATION :: female 10 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - ovaries, fallopian tubes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Parenteral

DOSE :: 168 mg/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

DOSE :: 24 mg/kg

SEX/DURATION :: male 42 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

DOSE :: 150 mg/kg

SEX/DURATION :: female 30 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 40 mg/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Fertility - other measures of fertility

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 40 mg/kg

SEX/DURATION :: female 10 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina Reproductive - Maternal Effects - other effects

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 2 gm/kg

SEX/DURATION :: female 14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - skin and skin appendages

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 24 mg/kg

SEX/DURATION :: female 3 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 200 ug/kg

SEX/DURATION :: male 20 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 14 mg/kg

SEX/DURATION :: male 70 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

DOSE :: 3420 ug/kg

SEX/DURATION :: male 90 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 30 mg/kg

SEX/DURATION :: female 1-3 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

DOSE :: 1500 ug/kg

SEX/DURATION :: female 1-3 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

MUTATION DATA

TEST SYSTEM :: Non-mammalian species

DOSE/DURATION :: 12 mg/8W (Intermittent)

REFERENCE :: JEZOAO Journal of Experimental Zoology. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1904- Volume(issue)/page/year: 205,403,1978

符号	GHS02, GHS06, GHS08
信号词	Danger
危害声明	H225-H301 + H311 + H331-H370
警示性声明	P210-P280-P302 + P352 + P312-P304 + P340 + P312-P370 + P378-P403 + P235
个人防护装备	Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
危害码 (欧洲)	Xn
风险声明 (欧洲)	R61
安全声明 (欧洲)	S53-S36/37/39-S45
危险品运输编码	UN1230 - class 3 - PG 2 - Methanol, solution
WGK德国	3
RTECS号	BV8052000
包装等级	II
危险类别	6.1

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