53872-60-9

• 常用中文名：(3AR,4R,5R,6AS)-六氢-5-羟基-4-[(1E,3R)-3-羟基-4-(3-三氟甲基)苯氧基-1-丁烯基]-2H-环戊并[B]呋喃-2-酮
• 常用英文名：Fluprostenol Lactone Diol
• CAS号：53872-60-9
• 分子式：C₁₈H₁₉F₃O₅
• 分子量：372.336
• 发布时间：2018-11-26 10:34:15
• 更新时间：2024-01-04 19:01:49

名称

• 中文名: (+)-(3aR,4R,5r,6aS)-六氢-5-羟基-4-[(1E,3R)-3-羟基-4-(3-三氟甲基)苯氧基-1-丁烯基]-2H-环戊并[b]呋喃-2-酮
• 英文名: (3aR,4R,5R,6aS)-5-hydroxy-4-[(3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-2-one
• 中文别名: 2H-环戊并[B]呋喃-2-酮,六氢-5-羟基-4-[(1E,3R)-3-羟基-4-[3-(三氟甲基)苯氧基]-1-丁烯-1-基]-,(3AR,4R,5R,6AS)-; (+)-(3AR,4R,5R,6AS)-六氢-5-羟基-4-[(1E,3R)-3-羟基-4-(3-三氟甲基)苯氧基-1-丁烯基]-2H-环戊并[B]呋喃-2-酮; 曲沃前列素中间体
• 英文别名: Travoprost Intermediate; 2H-Cyclopenta[b]furan-2-one, hexahydro-5-hydroxy-4-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]-, (3aS,4R,5R,6aR)-; (3aR,4R,5R,6aS)-5-Hydroxy-4-{(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-en-1-yl}hexahydro-2H-cyclopenta[b]furan-2-one; (3aR,4R,5R,6aS)-5-Hydroxy-4-((R,E)-3-hydroxy-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-2-one; (3aR,4R,5R,6aS)-5-hydroxy-4-((R,E)-3-hydroxy-4-(3-(trifluoromethyl)phenoxy)but-1-enyl)hexahydro-2H-cyclopenta[b]furan-2-one; (3aR,4R,5R,6aS)-5-Hydroxy-4-{(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl}hexahydro-2H-cyclopenta[b]furan-2-one; (3aS,4R,5R,6aR)-5-Hydroxy-4-{(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl}hexahydro-2H-cyclopenta[b]furan-2-one; 2H-Cyclopenta[b]furan-2-one, hexahydro-5-hydroxy-4-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]-, (3aR,4R,5R,6aS)-

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 520.6±50.0 °C at 760 mmHg
• 分子式: C₁₈H₁₉F₃O₅
• 分子量: 372.336
• 闪点: 268.6±30.1 °C
• 精确质量: 372.118469
• PSA: 75.99000
• LogP: 1.05
• 蒸汽压: 0.0±1.4 mmHg at 25°C
• 折射率: 1.583
• 储存条件: -20°C

安全

• 危害码 (欧洲): Xn

合成路线

1056147-98-8 ~% 53872-60-9

文献：WO2011/46569 A1, ; Page/Page column 67-68 ;

114488-91-4 ~% 53872-60-9

文献：Journal of Medicinal Chemistry, , vol. 24, # 11 p. 1353 - 1359

54142-64-2 ~% 53872-60-9

文献：Journal of Medicinal Chemistry, , vol. 24, # 11 p. 1353 - 1359

38754-71-1 ~% 53872-60-9

文献：Journal of Medicinal Chemistry, , vol. 24, # 11 p. 1353 - 1359

54094-19-8 ~% 53872-60-9

文献：Journal of Medicinal Chemistry, , vol. 24, # 11 p. 1353 - 1359

31752-99-5 ~% 53872-60-9

文献：WO2013/164729 A1, ;

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