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175277-21-1

175277-21-1结构式

常用中文名：N-甲基-3-硝基-5-(三氟甲基)-吡啶-2-胺
常用英文名：2-methylamino-3-nitro-5-(trifluoromethyl)pyridine
CAS号：175277-21-1
分子式：C₇H₆F₃N₃O₂
分子量：221.13700
相关类别：医药中间体杂环化合物吡啶类化合物吡啶衍生物
发布时间：2018-12-29 17:26:22
更新时间：2024-07-20 18:46:30

中文名	2-甲基氨-3-硝基-5-(三氟甲基)吡啶
英文名	N-methyl-3-nitro-5-(trifluoromethyl)pyridin-2-amine
中文别名	2-甲基氨基-3-硝基-5-三氟甲基吡啶
英文别名	N-methyl(3-nitro-5-trifluoromethylpyridin-2-yl)-amine HMS566K11 2-Methylamino-3-nitro-5-(trifluoromethyl)pyridine

密度	1.499g/cm3
沸点	267.6ºC at 760 mmHg
熔点	98-100ºC
分子式	C₇H₆F₃N₃O₂
分子量	221.13700
闪点	115.7ºC
精确质量	221.04100
PSA	70.74000
LogP	2.64650
蒸汽压	0.00807mmHg at 25°C
折射率	1.528
储存条件	室温，避光保存

Name:	N2-Methyl-3-nitro-5-(trifluoromethyl)pyridin-2-amine 97% Material Safety Data Sheet
Synonym:	2-Methylamino-3-nitro-5-(trifluoromethyl)pyridin
CAS:	175277-21-1

Section 1 - Chemical Product MSDS Name:N2-Methyl-3-nitro-5-(trifluoromethyl)pyridin-2-amine 97% Material Safety Data Sheet
Synonym:2-Methylamino-3-nitro-5-(trifluoromethyl)pyridin

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
175277-21-1	N2-Methyl-3-nitro-5-(trifluoromethyl)p	97%	unlisted

Hazard Symbols: XI
Risk Phrases: 36/37/38

Section 3 - HAZARDS IDENTIFICATION

EMERGENCY OVERVIEW
Irritating to eyes, respiratory system and skin.
Potential Health Effects
Eye:
Causes eye irritation.
Skin:
Causes skin irritation. May be harmful if absorbed through the skin.
Ingestion:
May cause irritation of the digestive tract. May be harmful if swallowed.
Inhalation:
Causes respiratory tract irritation. May be harmful if inhaled.
Chronic:
Not available.

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container.

Section 7 - HANDLING and STORAGE
Handling:
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage:
Store in a cool, dry place. Store in a tightly closed container.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 175277-21-1: Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: yellow
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 98 - 100 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C7H6F3N3O2
Molecular Weight: 221

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Not available.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Oxidizing agents, reducing agents, acids.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide, fluorine, hydrogen fluoride gas.
Hazardous Polymerization: Has not been reported

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 175277-21-1 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
N2-Methyl-3-nitro-5-(trifluoromethyl)pyridin-2-amine - Not listed by ACGIH, IARC, or NTP.

Section 12 - ECOLOGICAL INFORMATION

Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
No information available.
IMO
No information available.
RID/ADR
No information available.

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XI
Risk Phrases:
R 36/37/38 Irritating to eyes, respiratory system
and skin.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 37/39 Wear suitable gloves and eye/face
protection.
WGK (Water Danger/Protection)
CAS# 175277-21-1: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 175277-21-1 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 175277-21-1 is not listed on the TSCA inventory.
It is for research and development use only.

SECTION 16 - ADDITIONAL INFORMATION
N/A

危害码 (欧洲)	Xi
风险声明 (欧洲)	R36/37/38
安全声明 (欧洲)	S26-S37/39

937602-15-8

175277-21-1

文献：WO2010/125985 A1, ; Page/Page column 241-242 ;

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