87495-31-6

• 常用中文名：Disoxaril
• 常用英文名：Disoxaril
• CAS号：87495-31-6
• 分子式：C₂₀H₂₆N₂O₃
• 分子量：342.43200
• 发布时间：2016-05-11 02:04:50
• 更新时间：2024-01-13 20:45:35
• A picornavirus replication inhibitor by binding to the hydrophobic pocket within the VP1 coat protein, thus stabilizing the virion and blocking its uncoating..

名称

• 英文名: 5-[7-[4-(4,5-dihydro-1,3-oxazol-2-yl)phenoxy]heptyl]-3-methyl-1,2-oxazole
• 英文别名: DISOXARIL; Disoxarilo [Spanish]; Disoxarilum [Latin]; 5-{7-[4-(4,5-dihydro-2-oxazolyl)phenoxy]-heptyl}-3-methylisoxazole; Compound IV

物化性质

• 密度: 1.15g/cm3
• 沸点: 522.1ºC at 760 mmHg
• 分子式: C₂₀H₂₆N₂O₃
• 分子量: 342.43200
• 闪点: 269.6ºC
• 精确质量: 342.19400
• PSA: 56.85000
• LogP: 3.76740
• 折射率: 1.568

合成路线

93472-62-9 91945-38-9 ~% 87495-31-6

文献：Sterling Drug Inc. Patent: US4843087 A1, 1989 ;

81428-58-2 91945-38-9 ~76% 87495-31-6

文献：Diana, Guy D.; Oglesby, Richard C.; Akullian, Vahan; Carabateas, Phillip M.; Cutcliffe, David; et al. Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 383 - 388

300-87-8 ~% 87495-31-6

文献：Diana; McKinlay; Otto; Akullian; Oglesby Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1906 - 1910

629-03-8 ~% 87495-31-6

文献：Diana; McKinlay; Otto; Akullian; Oglesby Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1906 - 1910

91944-99-9 ~% 87495-31-6

文献：Diana; McKinlay; Otto; Akullian; Oglesby Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1906 - 1910

767-00-0 ~% 87495-31-6

文献：Diana; McKinlay; Otto; Akullian; Oglesby Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1906 - 1910

91944-98-8 ~% 87495-31-6

文献：Diana; McKinlay; Otto; Akullian; Oglesby Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1906 - 1910

98360-44-2 141-43-5 ~% 87495-31-6

文献：Diana; McKinlay; Otto; Akullian; Oglesby Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1906 - 1910