27018-21-9

• 常用中文名：5-甲氧基喹唑啉-2,4-二胺
• 常用英文名：5-Methoxyquinazoline-2,4-diamine
• CAS号：27018-21-9
• 分子式：C₉H₁₀N₄O
• 分子量：190.20200
• 发布时间：2018-12-26 20:44:59
• 更新时间：2024-01-05 16:53:44

名称

• 中文名: 5-甲氧基-2,4-二氨基喹唑啉
• 英文名: 5-Methoxy-quinazoline-2,4-diamine
• 英文别名: 5-methoxyquinazoline-2,4-diamine; 2,4-diamino-5-methoxyquinazoline; 2,4-Quinazolinediamine,5-methoxy; 5-Methoxy-2,4-chinazolindiamin; 5-Methoxy-2,4-diaminoquinazoline

物化性质

• 密度: 1.372g/cm3
• 沸点: 484.8ºC at 760mmHg
• 分子式: C₉H₁₀N₄O
• 分子量: 190.20200
• 闪点: 247ºC
• 精确质量: 190.08500
• PSA: 87.05000
• LogP: 1.96520
• 蒸汽压: 1.49E-09mmHg at 25°C
• 折射率: 1.732
• 储存条件: 室温

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : VA1367800 CHEMICAL NAME : 2,4-Quinazolinediamine, 5-methoxy- CAS REGISTRY NUMBER : 27018-21-9 BEILSTEIN REFERENCE NO. : 0746085 LAST UPDATED : 199612 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C9-H10-N4-O MOLECULAR WEIGHT : 190.23 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 33,434,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 137 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 33,434,1990

安全

• 海关编码: 2933990090

合成路线

593-85-1 67-56-1 1897-52-5 ~71% 27018-21-9

文献：Shanghai Institute Materia Medica, Chinese Academy Of Sciences; ZUO, Jianping; HU, Youhong; TANG, Wei; CHAO, Bo; TONG, Xiankun; LI, Dewen; JI, Feihong; HE, Peilan Patent: EP2649999 A1, 2013 ; Location in patent: Paragraph 0023 ;

124-46-9 94088-46-7 ~92% 27018-21-9

文献：Hynes, John B.; Pathak, Alpana; Panos, Constantina H.; Okeke, Claudia C. Journal of Heterocyclic Chemistry, 1988 , vol. 25, p. 1173 - 1177

1591-37-3 593-85-1 ~40% 27018-21-9

文献：Thurmond, John; Butchbach, Matthew E. R.; Palomo, Marty; Pease, Brian; Rao, Munagala; Bedell, Louis; Keyvan, Monica; Pai, Grace; Mishra, Rama; Haraldsson, Magnus; Andresson, Thorkell; Bragason, Gisli; Thosteinsdottir, Margret; Bjornsson, Jon Mar; Coovert, Daniel D.; Burghes, Arthur H. M.; Gurney, Mark E.; Singh, Jasbir Journal of Medicinal Chemistry, 2008 , vol. 51, # 3 p. 449 - 469

1897-52-5 ~% 27018-21-9

文献：SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; Zuo, Jianping; Hu, Youhong; Tang, Wei; Chao, Bo; Tong, Xiankun; Li, Dewen; Ji, Feihong; He, Peilan Patent: US2013/261139 A1, 2013 ;

1591-37-3 29671-92-9 ~% 27018-21-9

文献：Nelson; Rosowsky Antimicrobial Agents and Chemotherapy, 2001 , vol. 45, # 12 p. 3293 - 3303

海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%