102804-82-0

• 常用中文名：2-{[(4-甲氧基-3-甲基-2-吡啶基)甲基]硫基}-1H-苯并咪唑
• 常用英文名：2-{[(4-Methoxy-3-Methyl-2-Pyridinyl)Methyl]Sulfanyl}-1H-Benzimidazole
• CAS号：102804-82-0
• 分子式：C₁₅H₁₅N₃OS
• 分子量：285.36400
• 发布时间：2019-01-01 09:25:56
• 更新时间：2024-01-06 17:39:49

名称

• 中文名: 2-[(4-甲氧基-3-甲基吡啶-2-基)甲硫基]-1H-苯并咪唑
• 英文名: 2-[(4-methoxy-3-methyl-2-pyridinyl)-methylthio]-benzimidazole
• 中文别名: 雷贝拉唑EP杂质G; 2-{[(4-甲氧基-3-甲基-2-吡啶基)甲基]硫基}-1H-苯并咪唑
• 英文别名: 1H-Benzimidazole, 2-[[(4-methoxy-3-methyl-2-pyridinyl)methyl]thio]-; 2-{[(4-Methoxy-3-methyl-2-pyridinyl)methyl]sulfanyl}-1H-benzimidazole; 4-Desmethoxypropoxyl-4-methoxy S-Deoxo Rabeprazole; Rabeprazole EP Impurity G; 2-{[(4-Methoxy-3-Methyl-2-Pyridinyl)Methyl]Sulfanyl}-1H-Benzimidazole; Rabeprazole Impurity 12

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 504.7±60.0 °C at 760 mmHg
• 分子式: C₁₅H₁₅N₃OS
• 分子量: 285.36400
• 闪点: 259.0±32.9 °C
• 精确质量: 285.09400
• PSA: 76.10000
• LogP: 3.49
• 蒸汽压: 0.0±1.3 mmHg at 25°C
• 折射率: 1.678

合成路线

102625-98-9 134469-07-1 ~21% 102804-82-0

文献：Arigen, Pharmaceuticals, Inc. Patent: EP2103608 A1, 2009 ; Location in patent: Page/Page column 17 ;

86604-74-2 134469-07-1 ~90% 102804-82-0

文献：Pingili, R. Reddy; Jambula, M. Reddy; Ganta, M. Reddy; Ghanta, M. Reddy; Sajja; Sundaram; Boluggdu, V. Bhaskar Pharmazie, 2005 , vol. 60, # 11 p. 814 - 818

37699-43-7 ~% 102804-82-0

文献：Kuehler, Thomas C.; Swanson, Marianne; Shcherbuchin, Vladimir; Larsson, Hakan; Mellgard, Bjoern; Sjoestroem, Jan-Eric Journal of Medicinal Chemistry, 1998 , vol. 41, # 11 p. 1777 - 1788

86604-77-5 ~% 102804-82-0

文献：Kuehler, Thomas C.; Swanson, Marianne; Shcherbuchin, Vladimir; Larsson, Hakan; Mellgard, Bjoern; Sjoestroem, Jan-Eric Journal of Medicinal Chemistry, 1998 , vol. 41, # 11 p. 1777 - 1788

102625-96-7 ~% 102804-82-0

文献：Kuehler, Thomas C.; Swanson, Marianne; Shcherbuchin, Vladimir; Larsson, Hakan; Mellgard, Bjoern; Sjoestroem, Jan-Eric Journal of Medicinal Chemistry, 1998 , vol. 41, # 11 p. 1777 - 1788

102625-98-9 ~% 102804-82-0

文献：Kuehler, Thomas C.; Swanson, Marianne; Shcherbuchin, Vladimir; Larsson, Hakan; Mellgard, Bjoern; Sjoestroem, Jan-Eric Journal of Medicinal Chemistry, 1998 , vol. 41, # 11 p. 1777 - 1788

124473-12-7 134469-07-1 ~% 102804-82-0

文献：Kuehler, Thomas C.; Swanson, Marianne; Shcherbuchin, Vladimir; Larsson, Hakan; Mellgard, Bjoern; Sjoestroem, Jan-Eric Journal of Medicinal Chemistry, 1998 , vol. 41, # 11 p. 1777 - 1788

59886-90-7 ~% 102804-82-0

文献：Pingili, R. Reddy; Jambula, M. Reddy; Ganta, M. Reddy; Ghanta, M. Reddy; Sajja; Sundaram; Boluggdu, V. Bhaskar Pharmazie, 2005 , vol. 60, # 11 p. 814 - 818