73536-69-3

• 常用中文名：联苯双酯
• 常用英文名：Bifendatatum
• CAS号：73536-69-3
• 分子式：C₂₀H₁₈O₁₀
• 分子量：418.351
• 相关类别： 原料药 消化系统用药 肝病用药
• 发布时间：2018-02-06 08:00:00
• 更新时间：2024-01-02 23:47:32
• Bifendate (DDB) 是 Schisandrin C 的合成中间体,在慢性 B 型肝炎的研究中具有抗 HBV 功效。

名称

• 中文名: 联苯双酯
• 英文名: methyl 7-methoxy-4-(7-methoxy-5-methoxycarbonyl-1,3-benzodioxol-4-yl)-1,3-benzodioxole-5-carboxylate
• 中文别名: 右旋糖酐20; 4,4'-二甲氧基-5,6,5',6'-双亚甲二氧联苯-2,2'-二甲酸二甲酯
• 英文别名: dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylene dicarboxybiphenyl-2,2'-dicarboxylate; Dimethyl 7,7'-dimethoxy-4,4'-bi-1,3-benzodioxole-5,5'-dicarboxylate; Bifendate; [4,4'-Bi-1,3-benzodioxole]-5,5'-dicarboxylic acid, 7,7'-dimethoxy-, dimethyl ester; Bifendatatum; MFCD01751431; dimethyl 4,4'-dimethoxy-5,6,5',6'-dimethylenedioxybiphenylbiphenyl-2,2'-dicarboxylate; dimethyl 4,4'-dimethoxy-5,6,5',6'-dimethylenedioxybiphenyl-2,2'-dicarboxylate

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 606.9±55.0 °C at 760 mmHg
• 熔点: 181 °C
• 分子式: C₂₀H₁₈O₁₀
• 分子量: 418.351
• 闪点: 265.9±31.5 °C
• 精确质量: 418.089996
• PSA: 107.98000
• LogP: 2.23
• 外观性状: 固体;White to Almost white powder to crystal
• 蒸汽压: 0.0±1.7 mmHg at 25°C
• 折射率: 1.580
• 储存条件: 0-10°C;存放于惰性气体之中;避免空气,加热

生物活性

• 描述: Bifendate (DDB) 是 Schisandrin C 的合成中间体,在慢性 B 型肝炎的研究中具有抗 HBV 功效。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> HBV
• 参考文献:

  [1]. Cui S, et al. [Anti-HBV efficacy of bifendate in treatment of chronic hepatitis B, a primary study]. Zhonghua Yi Xue Za Zhi. 2002 Apr 25;82(8):538-40.

MSDS

Material Safety Data Sheet Section1. Identification of the substance Product Name: Bifendatatum Synonyms:7,7’-Dimethoxy-(4,4’-bi-1,3-benzodioxole)-5,5’-dicarboxylic acid dimethyl ester Section2. Hazards identification Harmful by inhalation, in contact with skin, and if swallowed. Section3. Composition/information on ingredients. Ingredient name:Bifendatatum CAS number:73536-69-3 Section4. First aid measures Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing contaminated clothing and shoes. If irritation persists, seek medical attention. Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical attention. Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention. Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention. Section5. Fire fighting measures In the event of a fire involving this material, alone or in combination with other materials, use dry powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus should be worn. Section6. Accidental release measures Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national standards. Respiratory precaution:Wear approved mask/respirator Hand precaution:Wear suitable gloves/gauntlets Skin protection:Wear suitable protective clothing Eye protection:Wear suitable eye protection Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container for disposal. See section 12. Environmental precautions: Do not allow material to enter drains or water courses. Section7. Handling and storage Handling:This product should be handled only by, or under the close supervision of, those properly qualified in the handling and use of potentially hazardous chemicals, who should take into account the fire, health and chemical hazard data given on this sheet. Store in closed vessels, refrigerated. Storage: Section8. Exposure Controls / Personal protection Engineering Controls: Use only in a chemical fume hood. Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles. General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse. Section9. Physical and chemical properties Appearance:Not specified Boiling point:No data No data Melting point: Flash point:No data Density:No data Molecular formula:C20H18O10 Molecular weight:418.4 Section10. Stability and reactivity Conditions to avoid: Heat, flames and sparks. Materials to avoid: Oxidizing agents. Possible hazardous combustion products: Carbon monoxide. Section11. Toxicological information No data. Section12. Ecological information No data. Section13. Disposal consideration Arrange disposal as special waste, by licensed disposal company, in consultation with local waste disposal authority, in accordance with national and regional regulations. Section14. Transportation information Non-harzardous for air and ground transportation. Section15. Regulatory information No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302, or have known CAS numbers that exceed the threshold reporting levels established by SARA Title III, Section 313. SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : DT4315000 CHEMICAL NAME : (4,4'-Bi-1,3-benzodioxole)-5,5'-dicarboxylic acid, 7,7'-dimethoxy-, dimethyl ester CAS REGISTRY NUMBER : 73536-69-3 LAST UPDATED : 199612 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C20-H18-O10 MOLECULAR WEIGHT : 418.38 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 42,62,1994

安全

• 危害码 (欧洲): Xi
• 海关编码: 2932992000

海关

海关编码	2932992000