303-70-8

• 常用中文名：11-[3-(dimethylamino)propyl]-5,6-dihydrobenzo[b][1]benzazepin-3-ol
• 常用英文名：11-[3-(dimethylamino)propyl]-5,6-dihydrobenzo[b][1]benzazepin-3-ol
• CAS号：303-70-8
• 分子式：C₁₉H₂₄N₂O
• 分子量：296.40700
• 发布时间：2016-08-20 04:31:31
• 更新时间：2024-01-03 13:17:41

名称

• 英文名: 11-[3-(dimethylamino)propyl]-5,6-dihydrobenzo[b][1]benzazepin-3-ol
• 英文别名: 5-(3-(Dimethylamino)propyl)-2-hydroxy-10,11-dihydro-5H-dibenz(b,f)azepine; 5H-Dibenz(b,f)azepin-2-ol,10,11-dihydro-5-(3-(dimethylamino)propyl); 5-(3-dimethylamino-propyl)-10,11-dihydro-5H-dibenzo[b,f]azepin-2-ol; 2-Hydroxy Imipramine; Hydroxyimipramine; N-(3-Dimethylamino-propyl)-2-hydroxy-iminodibenzyl; 2-OH-IP

物化性质

• 密度: 1.107g/cm3
• 沸点: 469ºC at 760mmHg
• 熔点: 130-132ºC
• 分子式: C₁₉H₂₄N₂O
• 分子量: 296.40700
• 闪点: 239.5ºC
• 精确质量: 296.18900
• PSA: 26.71000
• LogP: 3.64560
• 折射率: 1.593

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : HO2975500 CHEMICAL NAME : 5H-Dibenz(b,f)azepin-2-ol, 10,11-dihydro-5-(3-(dimethylamino)propyl)- CAS REGISTRY NUMBER : 303-70-8 BEILSTEIN REFERENCE NO. : 1547775 LAST UPDATED : 199803 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C19-H24-N2-O MOLECULAR WEIGHT : 296.45 WISWESSER LINE NOTATION : T C676 BN&T&J B3N1&1 FQ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2980 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 19,1617,1969 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 19 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 19,1617,1969 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 733 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 19,1617,1969 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 29 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : MPHEAE Medicina et Pharmacologia Experimentalis. (Basel, Switzerland) V.12-17, 1965-67. For publisher information, see PHMGBN. Volume(issue)/page/year: 15,187,1966 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 12500 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 19,1617,1969 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 300 mg/kg SEX/DURATION : female 8-12 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 19,1617,1969

安全

• 海关编码: 2933990090

合成路线

50-49-7 ~1% 796-28-1 303-70-8 94436-87-0

文献：Tetrahedron Letters, , vol. 52, # 7 p. 749 - 752

113-52-0 ~% 50-47-5 303-70-8

文献：Journal of Pharmacology and Experimental Therapeutics, , vol. 281, # 3 p. 1199 - 1210

134150-88-2 ~% 303-70-8

文献：Organic Preparations and Procedures International, , vol. 23, # 3 p. 365 - 372

113-52-0 ~% 303-70-8

文献：Organic Preparations and Procedures International, , vol. 23, # 3 p. 365 - 372

6487-79-2 ~% 303-70-8

文献：Organic Preparations and Procedures International, , vol. 23, # 3 p. 365 - 372

113-52-0 ~% 50-47-5 494-19-9 796-28-1 详细

文献：Journal of Pharmaceutical Sciences, , vol. 70, # 2 p. 151 - 155

113-52-0 ~% 494-19-9 796-28-1 303-70-8 详细

文献：Journal of Pharmaceutical Sciences, , vol. 70, # 2 p. 151 - 155

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海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%