89664-20-0

• 常用中文名：NOMIFENSINE
• 常用英文名：NOMIFENSINE
• CAS号：89664-20-0
• 分子式：C₁₆H₁₈N₂
• 分子量：238.32800
• 发布时间：2016-07-02 15:01:28
• 更新时间：2024-01-09 21:21:11

名称

• 英文名: (R)-nomifensine
• 英文别名: (-)-N-methylcystine; (1r)-l; Caulophyllin; (R)-(-)-2-Methyl-4-phenyl-8-amino-1,2,3,4-tetrahydroisochinolin; (1R)-1,2,3,4,5,6-hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one; 12-methyl-cytisin; Cytisine,12-methyl; (-)-cytisine; (-)-nomifensine; 1,5-methano-8h-pyrido(1,2a)(1,5)diazocin-8-one,1,2,3,4,5,6-hexahydro-3-methy; N-methyl cytisine; 12-Methylcytisine; (-)-N-methycytisine; METHYLCYTISINE,N-(P); 2-Methyl-4-phenyl-1,2,3,4-tetrahydro-8-isoquinolinamine

物化性质

• 熔点: 179-181ºC
• 分子式: C₁₆H₁₈N₂
• 分子量: 238.32800
• 精确质量: 238.14700
• PSA: 29.26000
• LogP: 3.36520

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : NW6801000 CHEMICAL NAME : 8-Isoquinolinamine, 1,2,3,4-tetrahydro-2-methyl-4-phenyl-, (R)- CAS REGISTRY NUMBER : 89664-20-0 LAST UPDATED : 199612 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C16-H18-N2 MOLECULAR WEIGHT : 238.36 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 49500 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 30,798,1987

合成路线

24526-64-5 ~% 89664-20-0 89664-18-6

文献：Pechulis, Anthony D.; Beck, James P.; Curry, Matt A.; Wolf, Mark A.; Harms, Arthur E.; Xi, Ning; Opalka, Chet; Sweet, Mark P.; Yang, Zhicai; Vellekoop, A. Samuel; Klos, Andrew M.; Crocker, Peter J.; Hassler, Carla; Laws, Mia; Kitchen, Douglas B.; Smith, Mark A.; Olson, Richard E.; Liu, Shuang; Molino, Bruce F. Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 23 p. 7219 - 7222

119810-30-9 ~% 89664-20-0 89664-18-6

文献：Pechulis, Anthony D.; Beck, James P.; Curry, Matt A.; Wolf, Mark A.; Harms, Arthur E.; Xi, Ning; Opalka, Chet; Sweet, Mark P.; Yang, Zhicai; Vellekoop, A. Samuel; Klos, Andrew M.; Crocker, Peter J.; Hassler, Carla; Laws, Mia; Kitchen, Douglas B.; Smith, Mark A.; Olson, Richard E.; Liu, Shuang; Molino, Bruce F. Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 23 p. 7219 - 7222

65514-97-8 ~% 89664-20-0 89664-18-6

文献：Pechulis, Anthony D.; Beck, James P.; Curry, Matt A.; Wolf, Mark A.; Harms, Arthur E.; Xi, Ning; Opalka, Chet; Sweet, Mark P.; Yang, Zhicai; Vellekoop, A. Samuel; Klos, Andrew M.; Crocker, Peter J.; Hassler, Carla; Laws, Mia; Kitchen, Douglas B.; Smith, Mark A.; Olson, Richard E.; Liu, Shuang; Molino, Bruce F. Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 23 p. 7219 - 7222

529-23-7 ~% 89664-20-0 89664-18-6

文献：Pechulis, Anthony D.; Beck, James P.; Curry, Matt A.; Wolf, Mark A.; Harms, Arthur E.; Xi, Ning; Opalka, Chet; Sweet, Mark P.; Yang, Zhicai; Vellekoop, A. Samuel; Klos, Andrew M.; Crocker, Peter J.; Hassler, Carla; Laws, Mia; Kitchen, Douglas B.; Smith, Mark A.; Olson, Richard E.; Liu, Shuang; Molino, Bruce F. Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 23 p. 7219 - 7222

66486-62-2 ~% 89664-20-0 89664-18-6

文献：Pechulis, Anthony D.; Beck, James P.; Curry, Matt A.; Wolf, Mark A.; Harms, Arthur E.; Xi, Ning; Opalka, Chet; Sweet, Mark P.; Yang, Zhicai; Vellekoop, A. Samuel; Klos, Andrew M.; Crocker, Peter J.; Hassler, Carla; Laws, Mia; Kitchen, Douglas B.; Smith, Mark A.; Olson, Richard E.; Liu, Shuang; Molino, Bruce F. Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 23 p. 7219 - 7222

1904-69-4 ~% 89664-20-0 89664-18-6

文献：Pechulis, Anthony D.; Beck, James P.; Curry, Matt A.; Wolf, Mark A.; Harms, Arthur E.; Xi, Ning; Opalka, Chet; Sweet, Mark P.; Yang, Zhicai; Vellekoop, A. Samuel; Klos, Andrew M.; Crocker, Peter J.; Hassler, Carla; Laws, Mia; Kitchen, Douglas B.; Smith, Mark A.; Olson, Richard E.; Liu, Shuang; Molino, Bruce F. Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 23 p. 7219 - 7222

24526-64-5 ~% 89664-20-0

文献：Kunstmann, Rudolf; Gerhards, Hermann; Kruse, Hansjoerg; Leven, Margret; Paulus, Erich F.; et al. Journal of Medicinal Chemistry, 1987 , vol. 30, # 5 p. 798 - 804

上下游产品

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24526-64-5 119810-30-9 65514-97-8 529-23-7
66486-62-2 1904-69-4
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