103255-66-9

• 常用中文名：帕秦克隆
• 常用英文名：Pazinaclone
• CAS号：103255-66-9
• 分子式：C₂₅H₂₃ClN₄O₄
• 分子量：478.92800
• 发布时间：2018-09-10 21:31:17
• 更新时间：2024-01-08 21:34:47

名称

• 中文名: 帕秦克隆
• 英文名: 2-(7-Chloro-1,8-naphthyridin-2-yl)-3-[2-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-2-oxoethyl]-3H-isoindol-1-one
• 中文别名: 帕曲星; 2-(7-氯-1,8-二氮萘-2-基)-3-[2-(1,4-二氧-8-氮杂螺[4.5]庚-8-基)-2-氧代乙基]-3H-异吲哚-1-酮
• 英文别名: 8-[[[2-(7-Chloro-1,8-naphthyridin-2-yl)-2,3-dihydro-3-oxo-1H-isoindol]-1-yl]acetyl]-1,4-dioxa-8-azaspiro[4.5]decane; Pazinaclone; DN-2327; 2-(7-chloro-1,8-naphthyridin-2-yl)-3-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)carbonylmethylisoindolin-1-one; 2-(7-Chloro-1,8-naphthyridine-2-yl)-3-[2-oxo-2-(1,4-dioxa-8-azaspiro[4.5]decane-8-yl)ethyl]isoindoline-1-one; 2-(7-chloro-1,8-naphthyridin-2-yl)-3-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-carbonylmethylisoindolin-1-one

物化性质

• 密度: 1.48g/cm3
• 沸点: 712.5ºC at 760mmHg
• 分子式: C₂₅H₂₃ClN₄O₄
• 分子量: 478.92800
• 闪点: 384.7ºC
• 精确质量: 478.14100
• PSA: 84.86000
• LogP: 3.74320
• 蒸汽压: 3.79E-20mmHg at 25°C
• 折射率: 1.709

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : JG6717092 CHEMICAL NAME : 1,4-Dioxa-8-azaspiro(4.5)decane, 8-((2-(7-chloro-1,8-naphthyridin-2-yl)-2,3-dihydro-3- oxo- 1H-isoindol-1-yl)acetyl)- CAS REGISTRY NUMBER : 103255-66-9 LAST UPDATED : 199703 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C25-H23-Cl-N4-O4 MOLECULAR WEIGHT : 478.97 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4695572

合成路线

103255-87-4 2942-58-7 177-11-7 ~% 103255-66-9

文献：US4695572 A1, ;

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