CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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YS4915000
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CHEMICAL NAME :
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Urea, 1-(2-chloroethyl)-3-(2,6-dioxo-3-piperidyl)-1-nitroso -
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CAS REGISTRY NUMBER :
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13909-02-9
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LAST UPDATED :
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199801
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DATA ITEMS CITED :
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12
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MOLECULAR FORMULA :
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C8-H11-Cl-N4-O4
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MOLECULAR WEIGHT :
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262.68
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WISWESSER LINE NOTATION :
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T6VMVTJ DMVNNO&2G
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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35700 ug/kg
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TOXIC EFFECTS :
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Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal)
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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15210 ug/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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22 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Mammal - dog
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DOSE/DURATION :
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3 mg/kg
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TOXIC EFFECTS :
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Behavioral - food intake (animal) Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - nausea or vomiting
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Primate - monkey
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DOSE/DURATION :
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10 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Mammal - dog
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DOSE/DURATION :
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15 mg/kg/10D-I
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TOXIC EFFECTS :
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Gastrointestinal - hypermotility, diarrhea Liver - changes in liver weight Nutritional and Gross Metabolic - body temperature increase
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Mammal - dog
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DOSE/DURATION :
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15 mg/kg/5D-I
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TOXIC EFFECTS :
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Gastrointestinal - hypermotility, diarrhea Liver - changes in liver weight Nutritional and Gross Metabolic - body temperature increase
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Primate - monkey
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DOSE/DURATION :
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50 mg/kg/5D-I
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TOXIC EFFECTS :
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Gastrointestinal - ulceration or bleeding from stomach Liver - changes in liver weight Related to Chronic Data - death
MUTATION DATA
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TYPE OF TEST :
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Mutation test systems - not otherwise specified
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TEST SYSTEM :
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Rodent - mouse Leukocyte
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DOSE/DURATION :
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16 mg/kg
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REFERENCE :
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INSSDM INSERM Symposium. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) No.1- 1975- Volume(issue)/page/year: 19,85,1981
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