514-61-4

• 常用中文名：甲基诺龙
• 常用英文名：Normethisteron
• CAS号：514-61-4
• 分子式：C₁₉H₂₈O₂
• 分子量：288.424
• 发布时间：2018-09-25 09:53:10
• 更新时间：2024-01-02 22:57:45

名称

• 中文名: 甲基诺龙
• 英文名: Normethandrone
• 中文别名: 甲诺酮
• 英文别名: 17a-Methyl-19-nortestosterone; 17α-Methyl-17β-hydroxy-19-nor-4-androsten-3-one; Orgasteron; Normethisterone; 17a-Methyl-17b-hydroxy-19-nor-4-androsten-3-one; 17b-Hydroxy-17a-methyloestr-4-en-3-one; EINECS 208-183-0; Metalutin; (17β)-17-Hydroxy-17-methylestr-4-en-3-one; Methalutin; (17b)-17-Hydroxy-17-methylestr-4-en-3-one; 17b-Hydroxy-17-methylestr-4-en-3-one; Estr-4-en-3-one, 17β-hydroxy-17-methyl-; Estr-4-en-3-one, 17-β-hydroxy-17-α-methyl-; 17α-Methylestrenolone; Normethandrolone; 17α-Methyl-19-nortestosterone; Matronal; Normetandrone; 19-Nortestosterone, 17-methyl-; Estr-4-en-3-one, 17-hydroxy-17-methyl-, (17β)-; 17b-Hydroxy-17a-methylestr-4-en-3-one; 17a-Methylestrenolone; 17-β-Hydroxy-17-α-methyloestr-4-en-3-one; 17-Methyl-19-nortestosterone; Lutenin; 17-β-Hydroxy-17-methylestr-4-en-3-one; MFCD00051139; Methylestrenolone; Orga-Steron; 17-α-Methyl-17-β-hydroxy-4-estren-3-one; 4-08-00-01001; 19-Nor-17a-methyltestosterone; 17β-Hydroxy-17-methyl-4-estren-3-on; Methyloestrenolone; Methylnortestosterone; 17a-Methyl-17b-hydroxy-4-estren-3-one; Orosteron

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 434.6±45.0 °C at 760 mmHg
• 熔点: 153-158°C
• 分子式: C₁₉H₂₈O₂
• 分子量: 288.424
• 闪点: 185.4±21.3 °C
• 精确质量: 288.208923
• PSA: 37.30000
• LogP: 3.54
• 外观性状: 白色固体
• 蒸汽压: 0.0±2.4 mmHg at 25°C
• 折射率: 1.560
• 储存条件: Controlled Substance, -20°C Freezer
• 分子结构:

  1、 摩尔折射率：83.11

  2、 摩尔体积（cm³/mol）：256.9

  3、 等张比容(90.2K)：663.6

  4、 表面张力(dyne/cm)：44.4

  5、 极化率(10-24cm³)：32.94

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : KG8000000 CHEMICAL NAME : Estr-4-en-3-one, 17-beta-hydroxy-17-alpha-methyl- CAS REGISTRY NUMBER : 514-61-4 BEILSTEIN REFERENCE NO. : 2622263 LAST UPDATED : 199612 DATA ITEMS CITED : 21 MOLECULAR FORMULA : C19-H28-O2 MOLECULAR WEIGHT : 288.47 WISWESSER LINE NOTATION : L E5 B666 OV MUTJ E1 FQ F1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 45 gm/kg/30D-C TOXIC EFFECTS : Endocrine - adrenal cortex hypoplasia Endocrine - other changes Blood - other changes REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 11,571,1977 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 9360 mg/kg/26W-I TOXIC EFFECTS : Kidney, Ureter, Bladder - changes in bladder weight Endocrine - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 11,588,1977 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 18 mg/kg SEX/DURATION : female 12-24 week(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) Reproductive - Specific Developmental Abnormalities - urogenital system REFERENCE : BRGOAY Bulletin de la Societe Royale Belge de Gynecologie et d'Obstetrique. (Brussels, Belgium) V.1-39, 1925-69. Discontinued. Volume(issue)/page/year: 28,137,1958 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 20 mg/kg SEX/DURATION : female 6-9 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 15,955,1978 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 200 mg/kg SEX/DURATION : female 6-9 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 15,955,1978 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 14 mg/kg SEX/DURATION : male 7 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands Reproductive - Paternal Effects - other effects on male REFERENCE : ACENA7 Acta Endocrinologica (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) V.1- 1948- Volume(issue)/page/year: 22,318,1956 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 112 mg/kg SEX/DURATION : male 14 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - testes, epididymis, sperm duct REFERENCE : ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877- Volume(issue)/page/year: 71,500,1958 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 60 mg/kg SEX/DURATION : female 12 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - menstrual cycle changes or disorders REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 29,95,1979 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 17500 ug/kg SEX/DURATION : female 15-21 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - urogenital system REFERENCE : ACENA7 Acta Endocrinologica (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) V.1- 1948- Volume(issue)/page/year: 38,128,1961 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 2 mg/kg SEX/DURATION : female 6-9 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 15,955,1978 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 20 mg/kg SEX/DURATION : female 6-9 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 15,955,1978 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Unreported DOSE : 150 mg/kg SEX/DURATION : female 30 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - uterus, cervix, vagina REFERENCE : RPHRA6 Recent Progress In Hormone Research. Proceedings of the Laurentian Hormone Conference. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1947- Volume(issue)/page/year: 20,395,1964 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 20 mg/kg SEX/DURATION : female 6-7 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 15,955,1978 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 200 mg/kg SEX/DURATION : female 6-7 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 15,955,1978 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 1600 ug/kg SEX/DURATION : female 1 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - uterus, cervix, vagina REFERENCE : 85GRAA "The Control of Fertility," Pincus, G., New York, Academic Press, 1965 Volume(issue)/page/year: -,150,1965 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 2 mg/kg SEX/DURATION : female 6-7 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 15,955,1978 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 20 mg/kg SEX/DURATION : female 6-7 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 15,955,1978 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 1280 ug/kg SEX/DURATION : female 1 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - uterus, cervix, vagina REFERENCE : 85GRAA "The Control of Fertility," Pincus, G., New York, Academic Press, 1965 Volume(issue)/page/year: -,150,1965 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 200 ug/kg SEX/DURATION : female 1 day(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - other measures of fertility REFERENCE : 85GRAA "The Control of Fertility," Pincus, G., New York, Academic Press, 1965 Volume(issue)/page/year: -,57,1965 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 5 mg/kg SEX/DURATION : female 5 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - uterus, cervix, vagina REFERENCE : ANREAK Anatomical Record. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1906/08- Volume(issue)/page/year: 142,469,1962 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 50 ug/kg SEX/DURATION : female 1 day(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - other measures of fertility REFERENCE : ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 59,695,1956

安全

• 风险声明 (欧洲): R20/21:Harmful by inhalation and in contact with skin . R65:Harmful: May cause lung damage if swallowed.
• 安全声明 (欧洲): S26-S36
• 海关编码: 2942000000

合成路线

434-22-0 ~% 514-61-4

文献：Djerassi et al. Journal of the American Chemical Society, 1954 , vol. 76, p. 4092

734-32-7 ~% 514-61-4

文献：Djerassi et al. Journal of the American Chemical Society, 1954 , vol. 76, p. 4092

2863-88-9 75-16-1 ~% 514-61-4

文献：Djerassi et al. Journal of the American Chemical Society, 1954 , vol. 76, p. 4092

5696-57-1 ~% 514-61-4

文献：Hill,J. et al. Helvetica Chimica Acta, 1966 , vol. 49, p. 292 - 311

75-16-1 96111-40-9 ~% 514-61-4

文献：De Ruggieri Gazzetta Chimica Italiana, 1957 , vol. 87, p. 795,802

上下游产品

上游产品  5
434-22-0 734-32-7 2863-88-9 75-16-1
5696-57-1
下游产品  3
302-76-1 7100-20-1 153-23-1

海关

海关编码	2942000000