223785-66-8

• 常用中文名：benzyl (2S)-2-(2-bromoacetyl)pyrrolidine-1-carboxylate
• 常用英文名：benzyl (2S)-2-(2-bromoacetyl)pyrrolidine-1-carboxylate
• CAS号：223785-66-8
• 分子式：C₁₄H₁₆BrNO₃
• 分子量：326.18600
• 发布时间：2016-04-16 13:20:03
• 更新时间：2024-01-14 13:50:38

名称

• 英文名: benzyl (2S)-2-(2-bromoacetyl)pyrrolidine-1-carboxylate
• 英文别名: 2,6-DIFLUOROPHENYLALANINE; 2-(S)-(2-bromo-1-oxoethyl)pyrrolidine-1-carboxylic acid benzyl ester; L-2,6-DIFLUOROPHENYL-ALANINE; L-Phenylalanine,2,6-difluoro; H-Phe(2,6-F2)-OH; 2,6-DIFLUORO-L-PHENYLALANINE; 2,6-DIFLUORO-DL-PHENYLALANINE; (S)-benzyl 2-(2-bromoacetyl)pyrrolidine-1-carboxylate; 2S-bromoacetyl N-carbobenzyloxy-L-pyrrolidine; 2(S)-2,6-difluorophenylalanine; N-Cbz-(S)-2-bromoacetylpyrrolidine; H-2,6-DIFLUORO-PHE-OH HCL; (S)-2,6-difluorophenylalanine; H-DL-Phe(2,6-F2)-OH

物化性质

• 分子式: C₁₄H₁₆BrNO₃
• 分子量: 326.18600
• 精确质量: 325.03100
• PSA: 46.61000
• LogP: 2.68950

合成路线

56633-71-7 ~97% 223785-66-8

文献：Bures, Filip; Kulhanek, Jiri Tetrahedron Asymmetry, 2005 , vol. 16, # 7 p. 1347 - 1354

1148-11-4 18107-18-1 ~% 223785-66-8

文献：ZALICUS PHARMACEUTICALS LTD.; PAJOUHESH, Hassan, A.; HOLLAND, Richard; ZHANG, Lingyun; PAJOUHESH, Hossein, O.; LAMONTAGNE, Jason; WHELAN, Brendan; SHORT, Glenn, F., III.; ROMERO, Donna, L. Patent: WO2013/131018 A1, 2013 ; Location in patent: Page/Page column 43; 44 ;

1148-11-4 ~% 223785-66-8

文献：MERCK SHARP and DOHME CORP.; DWYER, Michael P; KEERTIKAR, Kartik M; COBURN, Craig A; WU, Hao; HU, Bin; ZHONG, Bin; ZHANG, Chengren; DAN, Zhigang Patent: WO2012/40924 A1, 2012 ; WO 2012/040924 A1 Title/Abstract Full Text Show Details MERCK SHARP and DOHME CORP.; DWYER, Michael P; KEERTIKAR, Kartik M; COBURN, Craig A; WU, Hao; HU, Bin; ZHONG, Bin; ZHANG, Chengren; DAN, Zhigang; TONG, Ling; YU, Wensheng Patent: WO2012/41227 A1, 2012 ; WO 2012/041227 A1

501-53-1 ~% 223785-66-8

文献：ZALICUS PHARMACEUTICALS LTD.; PAJOUHESH, Hassan, A.; HOLLAND, Richard; ZHANG, Lingyun; PAJOUHESH, Hossein, O.; LAMONTAGNE, Jason; WHELAN, Brendan; SHORT, Glenn, F., III.; ROMERO, Donna, L. Patent: WO2013/131018 A1, 2013 ;

5211-23-4 ~% 223785-66-8

文献：ZALICUS PHARMACEUTICALS LTD.; PAJOUHESH, Hassan, A.; HOLLAND, Richard; ZHANG, Lingyun; PAJOUHESH, Hossein, O.; LAMONTAGNE, Jason; WHELAN, Brendan; SHORT, Glenn, F., III.; ROMERO, Donna, L. Patent: WO2013/131018 A1, 2013 ;

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