84017-99-2

• 常用中文名：(S)-11-DimethoxyMethyl-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione
• 常用英文名：(S)-11-DimethoxyMethyl-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione
• CAS号：84017-99-2
• 分子式：C₂₃H₂₂N₂O₆
• 分子量：422.43100
• 发布时间：2016-10-20 18:23:29
• 更新时间：2024-01-18 14:28:11

名称

• 英文名: (4S)-11-(Dimethoxymethyl)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]i ndolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• 英文别名: 7-dimethoxymethyl-1,3,5-cycloheptatriene; cyclohepta-2,4,6-trienecarbaldehyde dimethylacetal; Cycloheptatrien-7-carboxaldehyd-dimethylacetal; Cyclohepta-2,4,6-triencarbaldehyd-dimethylacetal; Cyclohepta-2,4,6-trien-1-carbaldehyd-dimethylacetal; 7-formyl-camptothecin dimethylacetal; 7-Dimethoxymethylcycloheptatrien; 7-dimethyl-acetal camptothecin; 7-Dimethoxymethylcamptothecin

物化性质

• 分子式: C₂₃H₂₂N₂O₆
• 分子量: 422.43100
• 精确质量: 422.14800
• PSA: 99.88000
• LogP: 2.37100

合成路线

67-56-1 7689-03-4 ~84% 84017-99-2

文献：Giannini, Giuseppe; Marzi, Mauro; Cabri, Walter; Marastoni, Elena; Battistuzzi, Gianfranco; Vesci, Loredana; Pisano, Claudio; Beretta, Giovanni Luca; Cesare, Michelandrea De; Zunino, Franco Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 9 p. 2910 - 2915

67-56-1 80758-83-4 ~% 84017-99-2

文献：SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. Patent: WO2009/16068 A1, 2009 ; Location in patent: Page/Page column 8 ;

67-56-1 78287-14-6 ~16% 84018-00-8 84017-99-2

文献：Sawada; Nokata; Furuta; Yokokura; Miyasaka Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 10 p. 2574 - 2580

67-56-1 78287-14-6 ~% 84017-99-2

文献：THRESHOLD PHARMACEUTICALS, INC.; CAI, Xiaohong; DUAN, Jian-Xin; MATTEUCCI, Mark; CAO, Yeyu; JIAO, Hailong Patent: WO2010/148138 A2, 2010 ; Location in patent: Page/Page column 68-69 ; WO 2010/148138 A2