851546-61-7

• 常用中文名：PSI-697
• 常用英文名：PSI-697
• CAS号：851546-61-7
• 分子式：C₂₁H₁₈ClNO₃
• 分子量：367.82600
• 相关类别： 研究领域 癌症
• 发布时间：2016-02-09 08:13:32
• 更新时间：2024-01-06 17:19:10
• PSI-697是一个P-selectin抑制剂。

名称

• 中文名: PSI-697
• 英文名: 2-[(4-chlorophenyl)methyl]-3-hydroxy-7,8,9,10-tetrahydrobenzo[h]quinoline-4-carboxylic acid
• 英文别名: 2-(4-Chloro-benzyl)-3-hydroxy-7,8,9,10-tetrahydro-benzo[h]quinoline-4-carboxylic acid; UNII-LH1XC916ME; PSI-697

物化性质

• 分子式: C₂₁H₁₈ClNO₃
• 分子量: 367.82600
• 精确质量: 367.09800
• PSA: 70.42000
• LogP: 4.76160
• 储存条件: 2-8℃

生物活性

• 描述: PSI-697是一个P-selectin抑制剂。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 癌症
• 参考文献:

  [1]. Myers DD Jr et al. Treatment with an oral small molecule inhibitor of P selectin (PSI-697) decreases vein wall injury in a rat stenosis model of venous thrombosis. J Vasc Surg. 2006 Sep;44(3):625-32.

  [2]. Bedard PW et al. Characterization of the novel P-selectin inhibitor PSI-697 [2-(4-chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[h] quinoline-4-carboxylic acid] in vitro and in rodent models of vascular inflammation and thrombosis. J Pharmacol Exp Ther.

  [3]. Myers DD Jr et al. Resolution of venous thrombosis using a novel oral small-molecule inhibitor of P-selectin (PSI-697) without anticoagulation. Thromb Haemost. 2007 Mar;97(3):400-7.

合成路线

92952-46-0 232267-03-7 ~39% 851546-61-7

文献：Wang, Youchu Patent: US2007/82923 A1, 2007 ; Location in patent: Page/Page column 12 ;

56955-38-5 721942-75-2 ~% 851546-61-7

文献：Wyeth Patent: US2005/101569 A1, 2005 ; Location in patent: Page/Page column 14 ;

92952-46-0 56955-38-5 ~41% 851546-61-7

文献：Kaila, Neelu; Janz, Kristin; Huang, Adrian; Moretto, Alessandro; DeBernardo, Silvano; Bedard, Patricia W.; Tam, Steve; Clerin, Valerie; Keith Jr., James C.; Tsao, Desiree H.H.; Sushkova, Natalia; Shaw, Gray D.; Camphausen, Raymond T.; Schaub, Robert G.; Wang, Qin Journal of Medicinal Chemistry, 2007 , vol. 50, # 1 p. 40 - 64

1878-66-6 ~% 851546-61-7

文献：Kaila, Neelu; Janz, Kristin; Huang, Adrian; Moretto, Alessandro; DeBernardo, Silvano; Bedard, Patricia W.; Tam, Steve; Clerin, Valerie; Keith Jr., James C.; Tsao, Desiree H.H.; Sushkova, Natalia; Shaw, Gray D.; Camphausen, Raymond T.; Schaub, Robert G.; Wang, Qin Journal of Medicinal Chemistry, 2007 , vol. 50, # 1 p. 40 - 64

33107-83-4 ~% 851546-61-7

文献：Kaila, Neelu; Janz, Kristin; Huang, Adrian; Moretto, Alessandro; DeBernardo, Silvano; Bedard, Patricia W.; Tam, Steve; Clerin, Valerie; Keith Jr., James C.; Tsao, Desiree H.H.; Sushkova, Natalia; Shaw, Gray D.; Camphausen, Raymond T.; Schaub, Robert G.; Wang, Qin Journal of Medicinal Chemistry, 2007 , vol. 50, # 1 p. 40 - 64

25026-34-0 ~% 851546-61-7

文献：Kaila, Neelu; Janz, Kristin; Huang, Adrian; Moretto, Alessandro; DeBernardo, Silvano; Bedard, Patricia W.; Tam, Steve; Clerin, Valerie; Keith Jr., James C.; Tsao, Desiree H.H.; Sushkova, Natalia; Shaw, Gray D.; Camphausen, Raymond T.; Schaub, Robert G.; Wang, Qin Journal of Medicinal Chemistry, 2007 , vol. 50, # 1 p. 40 - 64