852030-25-2

• 常用中文名：8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]-7H-purin-6-amine
• 常用英文名：8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]-7H-purin-6-amine
• CAS号：852030-25-2
• 分子式：C₁₂H₈BrN₅O₂S
• 分子量：366.19300
• 发布时间：2016-09-21 14:59:27
• 更新时间：2024-01-04 13:17:42

名称

• 英文名: 8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]-7H-purin-6-amine
• 英文别名: 8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]-9H-purin-6-amine; 8-(7-bromo-2,3-dihydro-benzo[1,4]dioxin-6-ylsulfanyl)adenine; 8-(6-Bromobenzo[d][1,3]dioxol-5-ylthio)-9H-purin-6-amine; 8-(6-bromo-benzo[1,3]dioxol-5-ylsulfanyl)adenine; 8-(6-bromo-3,4-methylenedioxyphenylthio)adenine; 8-(6-bromo-benzo[1,3]dioxol-5-ylsulfanyl)-9H-purin-6-ylamine; 1H-Purin-6-amine,8-[(6-bromo-1,3-benzodioxol-5-yl)thio]

物化性质

• 分子式: C₁₂H₈BrN₅O₂S
• 分子量: 366.19300
• 精确质量: 364.95800
• PSA: 124.24000
• LogP: 3.15870

合成路线

94670-76-5 7390-62-7 ~96% 852030-25-2

文献：SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH Patent: WO2006/84030 A2, 2006 ; Location in patent: Page/Page column 29-30 ;

7390-62-7 94670-76-5 ~47% 852030-25-2

文献：Qian, Changgeng; Cai, Xiong; Gould, Stephen; Zhai, Haixiao Patent: US2008/234297 A1, 2008 ; Location in patent: Page/Page column 36 ; US 20080234297 A1

1243536-37-9 ~70% 852030-25-2

文献：Sekiguchi, Hironori; Muranaka, Kazuhiro; Osada, Akiko; Ichikawa, Satoshi; Matsuda, Akira Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 15 p. 5732 - 5737

5279-32-3 7390-62-7 ~31% 852030-25-2

文献：Kim, Se-Ho; Bajji, Ashok; Tangallapally, Rajendra; Markovitz, Benjamin; Trovato, Richard; Shenderovich, Mark; Baichwal, Vijay; Bartel, Paul; Cimbora, Daniel; McKinnon, Rena; Robinson, Rosann; Papac, Damon; Wettstein, Daniel; Carlson, Robert; Yager, Kraig M. Journal of Medicinal Chemistry, 2012 , vol. 55, # 17 p. 7480 - 7501

2635-13-4 ~% 852030-25-2

文献：He, Huazhong; Zatorska, Danuta; Kim, Joungnam; Aguirre, Julia; Llauger, Laura; She, Yuhong; Wu, Nian; Immormino, Robert M.; Gewirth, Daniel T.; Chiosis, Gabriela Journal of Medicinal Chemistry, 2006 , vol. 49, # 1 p. 381 - 390