23313-68-0

• 常用中文名：维拉帕米盐酸盐
• 常用英文名：Verapamil hydrochloride
• CAS号：23313-68-0
• 分子式：C₂₇H₃₉ClN₂O₄
• 分子量：491.063
• 相关类别： 原料药 循环系统用药 抗高血压病药
• 发布时间：2018-05-11 08:00:00
• 更新时间：2024-01-02 13:51:35
• 【用途一】
  用于有机合成、医药工业;主要用于阵发性室上性心动过速，也用于心绞痛、高血压和肥厚型梗塞性心肌病

名称

• 中文名: 盐酸维拉帕米
• 英文名: Verapamil Hydrochloride
• 中文别名: 5-((3,4-二甲氧基苯乙基)(甲基)氨基)-2-(3,4-二甲氧基苯基)-2-异丙基戊腈; 异搏停 盐酸盐; 维拉帕米盐酸盐
• 英文别名: 2-(3,4-Dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(1-methylethyl)pentanonitrilhydrochlorid; 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(1-methylethyl)pentanenitrile hydrochloride; Izoptin Hydrochloride; Benzeneacetonitrile, α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)-, hydrochloride (1:1); MFCD00055208; (±)-Verapamil hydrochloride; 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile hydrochloride (1:1); Verogalid ER; 2-(3,4-Dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-isopropylpentanenitrile hydrochloride; a-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)benzeneacetonitrile Monohydrochloride; Verapamil Hydrochloride (Isoptin, Iproveratril, Calan); 5-[(3,4-dimethoxyphenethyl)(methyl)amino]-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile hydrochloride; 4-cyano-4-(3,4-dimethoxyphenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-N,5-dimethylhexan-1-aminium chloride; benzeneacetonitrile, a-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-, hydrochloride (1:1); verapamil hydrochloride; benzeneacetonitrile, α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)-, monohydrochloride; dl-Verapamil Hydrochloride; 2-(3,4-diméthoxyphényl)-5-{[2-(3,4-diméthoxyphényl)éthyl](méthyl)amino}-2-(1-méthyléthyl)pentanenitrile chlorhydrate; 2-(3,4-Dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-isopropylpentanenitrile hydrochloride (1:1); Veraptin; Arpamyl; Veracim; Vasolan; Verexamil; Drosteakard; EINECS 245-579-2; Lekoptin Retard

物化性质

• 沸点: 586.1ºC at 760 mmHg
• 熔点: 140-144ºC
• 分子式: C₂₇H₃₉ClN₂O₄
• 分子量: 491.063
• 闪点: 308.3ºC
• 精确质量: 490.259827
• PSA: 63.95000
• LogP: 5.89508
• 外观性状: powder | white
• 蒸汽压: 1.01E-13mmHg at 25°C
• 储存条件: 0-6°C
• 水溶解性: methanol: 50 mg/mL, clear, colorless

安全

• 危害码 (欧洲): T:Toxic;
• 风险声明 (欧洲): R23/24/25
• 安全声明 (欧洲): S36/37/39-S45
• 危险品运输编码: UN 2811 6.1/PG 3
• WGK德国: 3
• RTECS号: YV8320000
• 海关编码: 2926909090

合成路线

27339-25-9 13078-76-7 ~% 23313-68-0

文献：US2009/171110 A1, ; Page/Page column 6 ;

3490-06-0 27339-25-9 ~% 23313-68-0

文献：US4350636 A1, ;

上下游产品

上游产品  3
27339-25-9 13078-76-7 3490-06-0
下游产品  0

海关

海关编码	2926909090
中文概述	2926909090 其他腈基化合物. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%