86247-86-1

• 常用中文名：3,4-dihydro-8-(2-hydroxy-3-isopropylaminopropoxy)-2H-1-benzopyran-3-ol
• 常用英文名：3,4-dihydro-8-(2-hydroxy-3-isopropylaminopropoxy)-2H-1-benzopyran-3-ol
• CAS号：86247-86-1
• 分子式：C₁₅H₂₃NO₄
• 分子量：281.34700
• 发布时间：2017-04-30 12:06:34
• 更新时间：2024-01-17 17:13:56

名称

• 英文名: 8-[2-hydroxy-3-(propan-2-ylamino)propoxy]-3,4-dihydro-2H-chromen-3-ol
• 英文别名: 3,4-Dihydro-8-(2-hydroxy-3-(isopropylamino)propoxy)-2H-1-benzopyran-3-ol; Denitronipradilol; 2H-1-Benzopyran-3-ol,3,4-dihydro-8-(2-hydroxy-3-((1-methylethyl)amino)propoxy); 3,4-Dihydro-8-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-2H-1-benzopyran-3-ol; 3,4-dihydro-3(SR)-hydroxy-8-[2'(RS)-hydroxy-3'-isopropylamino]propoxy-2H-1-benzopyran

物化性质

• 分子式: C₁₅H₂₃NO₄
• 分子量: 281.34700
• 精确质量: 281.16300
• PSA: 70.95000
• LogP: 1.11100

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : DJ2885000 CHEMICAL NAME : 2H-1-Benzopyran-3-ol, 3,4-dihydro-8-(2-hydroxy-3-((1-methylethyl)amino)prop oxy)- CAS REGISTRY NUMBER : 86247-86-1 LAST UPDATED : 199212 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C15-H23-N-O4 MOLECULAR WEIGHT : 281.39 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1840 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 29,725,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 141 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 29,725,1985 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 21 gm/kg/5W-C TOXIC EFFECTS : Endocrine - changes in adrenal weight Blood - hemorrhage Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 30,437,1985