26685-57-4

• 常用中文名：H-GFRLTNFGYFEPG-OH
• 常用英文名：5,5-dimethyl-8-(3-methyloctan-2-yl)-2-prop-2-ynyl-3,4-dihydro-1H-chromeno[4,3-c]pyridin-10-ol
• CAS号：26685-57-4
• 分子式：C₂₆H₃₇NO₂
• 分子量：395.57700
• 发布时间：2018-12-27 13:18:45
• 更新时间：2024-01-02 12:50:26

名称

• 中文名: H-GFRLTNFGYFEPG-OH
• 英文名: 5,5-dimethyl-8-(3-methyloctan-2-yl)-2-prop-2-ynyl-3,4-dihydro-1H-chromeno[4,3-c]pyridin-10-ol
• 中文别名: GLY-PHE-ARG-LEU-THR-ASN-PHE-GLY-TYR-PHE-GLU-PRO-GLY

物化性质

• 密度: 1.07g/cm3
• 沸点: 517.8ºC at 760mmHg
• 分子式: C₂₆H₃₇NO₂
• 分子量: 395.57700
• 闪点: 267ºC
• 精确质量: 395.28200
• PSA: 32.70000
• LogP: 5.91350
• 蒸汽压: 2.42E-11mmHg at 25°C
• 折射率: 1.565

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : DJ3170000 CHEMICAL NAME : 5H-(1)Benzopyrano(4,3-c)pyridine, 1,2,3,4-tetrahydro-5,5-dimethyl-8-(1,2-dimethylheptyl )- 10-hydroxy-2-(2-propynyl)- CAS REGISTRY NUMBER : 26685-57-4 LAST UPDATED : 199107 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C26-H37-N-O2 MOLECULAR WEIGHT : 395.64 WISWESSER LINE NOTATION : T B666 DN IO HHT&&J D2UU1 H1 H1 LY1&Y5&1 NQ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 900 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 19,454,1976 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 19,454,1976 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 40 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - ataxia Behavioral - irritability REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 19,445,1976

合成路线

26685-47-2 ~% 26685-57-4

文献：Pars; Granchelli; Razdan; Keller; Teiger; Rosenberg; Harris Journal of Medicinal Chemistry, 1976 , vol. 19, # 4 p. 445 - 454

271242-28-5 ~% 26685-57-4

文献：Buchwald; Browne; Wu; Ji; Bodor Pharmazie, 2000 , vol. 55, # 3 p. 196 - 201

26685-53-0 106-96-7 ~% 26685-57-4

文献：Pars; Granchelli; Razdan; Keller; Teiger; Rosenberg; Harris Journal of Medicinal Chemistry, 1976 , vol. 19, # 4 p. 445 - 454

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26685-47-2 271242-28-5 26685-53-0 106-96-7
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