503-01-5

• 常用中文名：异美汀
• 常用英文名：isometheptene
• CAS号：503-01-5
• 分子式：C₉H₁₉N
• 分子量：141.25400
• 相关类别： 原料药 消化系统用药 胃肠解痉药
• 发布时间：2018-08-27 12:12:53
• 更新时间：2024-01-10 23:36:27

名称

• 中文名: 异美汀
• 英文名: N,6-dimethylhept-5-en-2-amine
• 英文别名: Octinum; Methylisooctenylamine; N,6-dimethyl-5-hepten-2-amine; Octanil; Methyloctenylamine; Octon; 4-Hexenylamine,N,1,5-trimethyl; Octin; Isometheptene; 5-Hepten-2-amine,N,6-dimethyl; Isonyl

物化性质

• 密度: 0.786g/cm3
• 沸点: 177.5ºC at 760mmHg
• 分子式: C₉H₁₉N
• 分子量: 141.25400
• 闪点: 46.3ºC
• 精确质量: 141.15200
• PSA: 12.03000
• LogP: 2.73160
• 外观性状: 无色,油性液体
• 折射率: 1.438

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : MP9100000 CHEMICAL NAME : 4-Hexenylamine, N,1,5-trimethyl- CAS REGISTRY NUMBER : 503-01-5 BEILSTEIN REFERENCE NO. : 1742093 LAST UPDATED : 199701 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C9-H19-N MOLECULAR WEIGHT : 141.29 WISWESSER LINE NOTATION : 1Y1&U3Y1&M1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 134 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 116,377,1956 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 42 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 116,377,1956 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 100 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : FDMU** "Zur Pharmakologie des Octins, Dissertation," Fiegenbaum, A., Pharmakologischen Institut der Westfalischen Wilhelms-Universitat, Munster, Fed. Rep. Ger., 1935 Volume(issue)/page/year: -,-,1935 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 34 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 227,71,1955 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 50 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : FDMU** "Zur Pharmakologie des Octins, Dissertation," Fiegenbaum, A., Pharmakologischen Institut der Westfalischen Wilhelms-Universitat, Munster, Fed. Rep. Ger., 1935 Volume(issue)/page/year: -,-,1935

安全

• 海关编码: 2921199090

合成路线

110-93-0 74-89-5 ~% 503-01-5

文献：Bilhuber Inc. Patent: AT134561 ; Full Text Show Details Bilhuber Inc. Patent: US1972450 , 1931 ; Full Text Show Details Knoll A.G. Patent: CH163535 , 1932 ; Full Text Show Details Knoll A.G. Patent: DE617536 , 1931 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 21, p. 680,682 Full Text Show Details Knoll A.G. Patent: DE617879 , 1932 ;

110-93-0 593-51-1 ~% 503-01-5

文献：Taylor,W.G.; Coutts,R. Canadian Journal of Chemistry, 1979 , vol. 57, p. 2103 - 2107

50-00-0 22462-79-9 ~% 503-01-5

文献：Knoll A.G. Patent: DE617596 , 1931 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 21, p. 684 Full Text Show Details Knoll A.G. Patent: CH166214 , 1932 ;

110-93-0 ~% 503-01-5

文献：Knoll A.G. Patent: DE617596 , 1931 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 21, p. 684

上下游产品

上游产品  5
110-93-0 74-89-5 593-51-1 50-00-0
22462-79-9
下游产品  1
63958-97-4

海关

海关编码	2921199090
中文概述	2921199090 其他无环单胺及其衍生物及其盐。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	2921199090 other acyclic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%