376348-77-5

• 常用中文名：4,4-DIFLUORO-N-((1S)-3-HYDROXY-1-PHENYLPROPYL)CYCLOHEXANE-1-CARBOXAMIDE
• 常用英文名：4,4-DIFLUORO-N-((1S)-3-HYDROXY-1-PHENYLPROPYL)CYCLOHEXANE-1-CARBOXAMIDE
• CAS号：376348-77-5
• 分子式：C₁₆H₂₁F₂NO₂
• 分子量：297.340
• 发布时间：2016-10-03 14:59:15
• 更新时间：2024-01-14 14:25:23

名称

• 英文名: 4,4-Difluoro-N-[(1S)-3-hydroxy-1-phenylpropyl]cyclohexanecarboxam ide
• 中文别名: 4,4-二氟-N-((1S)-3-羟基-1-苯基丙基)环己烷甲酰胺
• 英文别名: 4-heptylidene difluoride; Heptane,4,4-difluoro; 4,4-Difluoro-N-[(1S)-3-hydroxy-1-phenylpropyl]cyclohexanecarboxamide; L6TJ AF AF DVMYR&2Q &&S Form; (S)-4,4-difluoro-N-(3-hydroxy-1-phenylpropyl)cyclohexanecarboxamide; 4,4-Difluorheptan; Cyclohexanecarboxamide, 4,4-difluoro-N-[(1S)-3-hydroxy-1-phenylpropyl]-; 4,4-difluoro-heptane; (S)-4,4-Difluoro-N-(3-hydroxy-1-phenylpropyl)cyclohexane-1-carboxamide

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 502.7±50.0 °C at 760 mmHg
• 分子式: C₁₆H₂₁F₂NO₂
• 分子量: 297.340
• 闪点: 257.9±30.1 °C
• 精确质量: 297.154022
• PSA: 52.82000
• LogP: 1.58
• 蒸汽压: 0.0±1.4 mmHg at 25°C
• 折射率: 1.526

合成路线

122665-97-8 82769-76-4 ~% 376348-77-5

文献：ASTRAZENECA AB Patent: WO2006/1752 A1, 2006 ; Location in patent: Page/Page column 70 ; WO 2006/001752 A1

376348-78-6 ~% 376348-77-5

文献：Zhao, Gui-Ling; Lin, Shuangzheng; Korotvicka, Ales; Deiana, Luca; Kullberg, Martin; Cordova, Armando Advanced Synthesis and Catalysis, 2010 , vol. 352, # 13 p. 2291 - 2298

376348-75-3 ~% 376348-77-5

文献：Ahman, Jens; Birch, Melissa; Haycock-Lewandowski, Sarah J.; Long, James; Wilder, Alexander Organic Process Research and Development, 2008 , vol. 12, # 6 p. 1104 - 1113

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