478837-18-2

• 常用中文名：3-羟基-8-氮杂双环[3.2.1]辛烷-8-羧酸叔丁酯
• 常用英文名：tert-Butyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate
• CAS号：478837-18-2
• 分子式：C₁₂H₂₁NO₃
• 分子量：227.30000
• 发布时间：2017-09-17 14:28:03
• 更新时间：2024-01-31 20:47:38

名称

• 中文名: 3-羟基-8-氮杂双环[3.2.1]辛烷-8-羧酸叔丁酯
• 英文名: 2-Methyl-2-propanyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxy late
• 英文别名: (3-endo)-tert-butyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate; tert-Butyl 3-endo-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate; 3-exo-3-hydroxy-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester; 3a-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylic acid t-butyl ester; (1R,3S,5S)-3-hydroxy-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester; 3-hydroxy-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester; tert-butyl exo-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate; Boc-pseudotropine; (1R,3R,5S)-tert-butyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate; (cis)-3-hydroxy-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester

物化性质

• 分子式: C₁₂H₂₁NO₃
• 分子量: 227.30000
• 精确质量: 227.15200
• PSA: 49.77000
• LogP: 1.84710
• 储存条件: 2-8°C，干燥密封

合成路线

185099-67-6 ~94% 478837-18-2

文献：EXELIXIS, INC.; RICE, Kenneth Patent: WO2012/71509 A2, 2012 ; Location in patent: Page/Page column 166 ; WO 2012/071509 A2

7432-11-3 24424-99-5 ~% 478837-18-2

文献：Skjaerbaek, Niels; Koch, Kristian Norup; Mikael Friberg, Bo Lennart; Tolf, Bo-Ragnar Patent: US2005/209226 A1, 2005 ; US 20050209226 A1

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