173531-58-3

• 常用中文名：磷酸萘酚喹
• 常用英文名：Naphthoquine Phosphate
• CAS号：173531-58-3
• 分子式：C₂₄H₃₄ClN₃O₉P₂
• 分子量：605.942
• 相关类别： 原料药 抗寄生虫病药 抗疟药
• 发布时间：2018-08-17 11:58:29
• 更新时间：2024-01-02 18:12:56
• Naphthoquine磷酸盐是抗疟疾化合物。

名称

• 中文名: 磷酸萘酚喹
• 英文名: 2-[(tert-butylamino)methyl]-4-[(7-chloroquinolin-4-yl)amino]-5,6,7,8-tetrahydronaphthalen-1-ol,phosphoric acid
• 英文别名: 1-Naphthalenol, 4-[(7-chloro-4-quinolinyl)amino]-2-[[(1,1-dimethylethyl)amino]methyl]-5,6,7,8-tetrahydro-, phosphate (1:2) (salt); Naphthoquine phosphate; 4-[(7-Chloro-4-quinolinyl)amino]-2-{[(2-methyl-2-propanyl)amino]methyl}-5,6,7,8-tetrahydro-1-naphthalenol phosphate (1:2); CS-0739; Naphthoquine (phosphate)

物化性质

• 分子式: C₂₄H₃₄ClN₃O₉P₂
• 分子量: 605.942
• 精确质量: 605.145874
• PSA: 232.32000
• LogP: 4.71100
• 储存条件: 2-8℃

生物活性

• 描述: Naphthoquine磷酸盐是抗疟疾化合物。
• 相关类别:
  信号通路 >> 抗感染 >> 寄生物
  研究领域 >> 其他
• 参考文献:

  [1]. Qu HY, et al. Single-dose safety, pharmacokinetics, and food effects studies of compound naphthoquine phosphate tablets in healthy volunteers. J Clin Pharmacol. 2010 Nov;50(11):1310-8.

  [2]. Tun T, et al. Efficacy of oral single dose therapy with artemisinin-naphthoquine phosphate in uncomplicated falciparum malaria. Acta Trop. 2009 Sep;111(3):275-8.

  [3]. Wang JY, et al. [Therapeutic efficacy of naphthoquine phosphate combined with artemisinine against Plasmodium knowlesi]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2008 Dec 30;26(6):442-444.

  [4]. Wang JY, et al. Naphthoquine phosphate and its combination with artemisinine. Acta Trop. 2004 Feb;89(3):375-81.

  [5]. Wang SQ, et al. Therapeutic effect of dihydroartemisinin combined with naphthoquine phosphate in patients with falciparum malaria .Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2002;20(3):180-2.

  [6]. El-Beshbishi SN, et al. First insight into the effect of single oral dose therapy with artemisinin-naphthoquine phosphate combination in a mouse model of Schistosoma mansoni infection. Int J Parasitol. 2013 Jun;43(7):521-530.