714971-09-2

• 常用中文名：BMS-599626
• 常用英文名：AC480 (BMS-599626)
• CAS号：714971-09-2
• 分子式：C₂₇H₂₇FN₈O₃
• 分子量：530.554
• 相关类别： 生物化工 抑制剂 蛋白酪氨酸激酶
• 发布时间：2018-12-18 07:39:58
• 更新时间：2024-01-12 17:53:56
• AC480 (BMS-599626)是 HER1和HER2选择性高效抑制剂,IC50分别为20 nM和30 nM,比针对VEGFR2,c-Kit,Lck,MET的抑制性强100倍以上。

名称

• 中文名: [4-[[1-[(3-氟苯基)甲基]-1H-咪唑-5-基]氨基]-5-甲基吡咯[2,1-f][1,2,4]三嗪-6-基]-氨基甲酸-(3S)-3-吗啉甲酯
• 英文名: [(3S)-morpholin-3-yl]methyl N-[4-[[1-[(3-fluorophenyl)methyl]indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamate
• 英文别名: Carbamic acid, N-[4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-, (3S)-3-morpholinylmethyl ester; (S)-Morpholin-3-ylmethyl (4-((1-(3-fluorobenzyl)-1H-indazol-5-yl)amino)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)carbamate; (3S)-3-morpholinylmethyl ester; (S)-morpholin-3-ylmethyl-4-(1-(3-fluorobenzyl)-1H-indazol-5-ylamino)-5-methylpyrolo[1,2-f][1,2,4]triazin-6-ylcarbamate; cc-393; [4-[[1-(3-fluorophenyl)methyl]-1H-indazol-5-ylamino]-5-methyl-pyrrolo[2,1-f][1,2,4]triazin-6-yl]-carbamic acid; (3S)-3-Morpholinylmethyl (4-{[1-(3-fluorobenzyl)-1H-indazol-5-yl]amino}-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)carbamate; [4-[[1-(3-fluorophenyl)methyl]-1H-indazol-5-ylamino]-5-methyl-pyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamic acid (3S)-3-morpholinylmethyl ester; [4-[[1-(3-fluorophenyl)methyl]-1H-indazol-5-ylamino]-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-yl]carbamic acid (3S)-3-morpholinylmethyl ester; BMS-599626; AC480

物化性质

• 密度: 1.5±0.1 g/cm3
• 分子式: C₂₇H₂₇FN₈O₃
• 分子量: 530.554
• 精确质量: 530.218994
• PSA: 119.63000
• LogP: 1.47
• 外观性状: 固体;White to Light yellow to Light orange powder to crystal
• 折射率: 1.720
• 储存条件: <0°C;避免加热

生物活性

• 描述: AC480 (BMS-599626)是 HER1和HER2选择性高效抑制剂,IC50分别为20 nM和30 nM,比针对VEGFR2,c-Kit,Lck,MET的抑制性强100倍以上。
• 相关类别:
  研究领域 >> 癌症
• 参考文献:

  [1]. Wong TW, et al. Preclinical antitumor activity of BMS-599626, a pan-HER kinase inhibitor that inhibits HER1/HER2 homodimer and heterodimer signaling. Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):6186-93.

  [2]. Torres MA, et al. AC480, formerly BMS-599626, a pan Her inhibitor, enhances radiosensitivity and radioresponse of head and neck squamous cell carcinoma cells in vitro and in vivo. Invest New Drugs. 2011 Aug;29(4):554-61.

安全

• 危险品运输编码: NONH for all modes of transport

合成路线

714971-12-7 ~77% 714971-09-2

文献：BRISTOL-MYERS SQUIBB COMPANY Patent: WO2005/58245 A2, 2005 ; Location in patent: Page/Page column 37-38 ; WO 2005/058245 A2

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