3123-89-5

• 常用中文名：Acetamide,N-[(7S)-10-amino-5,6,7,9-tetrahydro-1,2,3-trimethoxy-9-oxobenzo[a]heptalen-7-yl]-
• 常用英文名：Acetamide,N-[(7S)-10-amino-5,6,7,9-tetrahydro-1,2,3-trimethoxy-9-oxobenzo[a]heptalen-7-yl]-
• CAS号：3123-89-5
• 分子式：C₂₁H₂₄N₂O₅
• 分子量：384.42600
• 发布时间：2017-10-12 07:46:53
• 更新时间：2024-02-01 17:52:40

名称

• 英文名: N-[(7S)-10-amino-1,2,3-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
• 英文别名: Colchicine amide; Colchicein-amid; Colchicamide; Colchiceinamide; Colchicamide (VAN); (S)--7-Acetylamino-10-amino-1,2,3-trimethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-on; N-((S)-10-amino-1,2,3-trimethoxy-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamide; 14-Aminocolchicide; 10-demethoxy-10-N-aminocolchicine; Colchicamid; SKF 3192; Colchicenamide; Colchicide,14-amino; N-((S)-10-Amino-1,2,3-trimethoxy-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamid

物化性质

• 密度: 1.28g/cm3
• 沸点: 722.2ºC at 760 mmHg
• 分子式: C₂₁H₂₄N₂O₅
• 分子量: 384.42600
• 闪点: 390.6ºC
• 精确质量: 384.16900
• PSA: 99.88000
• LogP: 3.41730
• 折射率: 1.61

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : GH0710000 CHEMICAL NAME : Colchicine, 10-amino-10-demethoxy- CAS REGISTRY NUMBER : 3123-89-5 BEILSTEIN REFERENCE NO. : 2824077 LAST UPDATED : 199703 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C21-H24-N2-O5 MOLECULAR WEIGHT : 384.47 WISWESSER LINE NOTATION : L B677 MV&T&J CO1 DO1 EO1 JMV1 NZ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 29600 ug/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea REFERENCE : PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 20,284,1957 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 33500 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 98,236,1954 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 43 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea REFERENCE : PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 20,284,1957 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Mammal - cat DOSE/DURATION : 8900 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig, Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC. Volume(issue)/page/year: 85,235,1920 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Amphibian - frog DOSE/DURATION : 160 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig, Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC. Volume(issue)/page/year: 85,235,1920 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 12 mg/kg/24D-I TOXIC EFFECTS : Gastrointestinal - alteration in gastric secretion Gastrointestinal - nausea or vomiting Blood - changes in bone marrow (not otherwise specified) REFERENCE : CMJODS Chinese Medical Journal (Beijing, English Edition). (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1975- Adopted vol. no. 92 in 1979. Volume(issue)/page/year: 93,188,1980

合成路线

64-86-8 ~60% 3123-89-5

文献：UNIVERSITY OF BRADFORD Patent: WO2008/125800 A2, 2008 ; Location in patent: Page/Page column 16 ;

64-86-8 7664-41-7 ~% 3123-89-5

文献：Santavy Chemicke Listy, 1952 , vol. 46, p. 280,284 Chem.Abstr., 1953 , p. 4325 Full Text Show Details Horowitz; Ullyot Journal of the American Chemical Society, 1952 , vol. 74, p. 587,591

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